Dear Margaroo, As I mentioned earlier, NSAIDs (including Naprosyn) increase lithium levels by about 20%. So, if someone is on a low-ish dose to begin with, with a low-ish lithium level, then likely occasional NSAID use is no nig deal. On the other hand, for people taking higher lithium doses with blood levels that hiver closer to 0.9-1 or more, then pushing the level up higher could potentially be overkill. On the other other hand, to become truly toxic on lithium often means super-high blood levels (ie, over 1.5), which is a much bigger leap than one might expect from just a 20% rise. - Dr. G.View Thread
No....other than that acetopminophen if used long-term can tax your liver (unrelated to lithium use) and hydrocodone can cause sedation (again unrelated to co-administration with lithium). - Dr. G.View Thread
Nonsteroidal anti-inflammatory drugs (eg, Motrin/ibuprofen, Advil, Naprosyn) raise lithium levels by about 20%. We often therefore say "not" to combine NSAIDs with lithium...but if a doctor advises a course of NSAIDs, lithium can be dropped by about 20% (eg, if taking 900 mg/day, reduce by 150 mg) to compensate...after discussing with the prescriber.View Thread
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