I have been on Cymbalta since 2012..suffice it to say it has been the WORST year and a half of my life. At first it diminished the depression, and I started to feel normal again. I'm also bipolar, and the doctor I've been seeing decided it was the best fit for me. After being in my system for awhile, it became a nightmare. Aggravation, lethargy, weight gain, moodiness, etc. I hated the way it made me feel and my entire persona changed. I tried going off of it cold turkey, but it was akin to going through detox. I was climbing the walls, my ears felt as though they were full of sand, and the nausea and dizziness were enough to make me regret ever taking it. After discussing this with my doctor, I stepped down to 30 mg from 60, and slowly began the leveling off of this so called 'wonder drug'. It has now been 3 days since I've been off of Cymbalta after stepping down, and it will take me awhile to get rid of this crap out of my system. We are going to try Wellbutrin (which will help with my smoking, which I picked up after the mood changes made me more irritable), and see how it works. I have heard from others that Cymbalta has helped them tremendously. I'm happy for them, but for me, this is one drug I will NEVER recommend to anyone.