Research in the UK shows that 62 per cent of people under 40 have never had a cholesterol test, with only one in 10 saying they have asked their doctor to test them for high cholesterol.
Furthermore, almost 40 per cent have never looked into whether there is a history of high cholesterol in their family, while almost 30 per cent know there is a history but have never spoken to their GP about it.
The team compared the baseline characteristics of 153 patients who died during an average 8.2 years of follow-up and 218 who survived. The researchers assumed that risk for mortality would be consistently high among the study participants. However, 60 percent were still living after more than eight years. The use of cholesterol-lowering statins at the baseline exam was the only modifiable risk factor identified to be protective against mortality. The participants taking statins at the beginning of the study had a 50 percent increase of being alive as compared to those who didn't.
We're finding more and more off label uses for statins every day;
"Patients who received statins had a 43 percent reduction in the odds of having Barrett's esophagus compared to non-users," said study author Hashem B. El-Serag, MD, MPH, from the Houston VA Medical Center and Baylor College of Medicine, Houston, TX. "This is the first study to find a significantly lower risk of Barrett's esophagus with statin use, independent of other known risk factors. Further studies are needed to examine this association."
Overwhelming evidence now shows that the benefits of statins vastly outweigh the risk of side effects, a group of health experts has claimed.
Many GPs and patients are concerned about their over-prescription, which some say will needlessly expose people to side effects such as muscle pain and diabetes. But the group of leading cardiologists and epidemiologists dismissed fears about side effects as misrepresentative and misleading.
Fantastic! This doctor effectively eradicated heart disease from his patients under 70, just incredible.
Before most doctors had heard of statins, Dr Revill was orchestrating a crusade against heart disease. This, he claims, saved more than 100 lives and reduced the death rate from heart disease to near zero in the deprived Greenhill area of south Sheffield, where he practiced.
Crucially, say Nice experts, the crusading doctor left a little-studied legacy of 30 years' worth of "meticulously collected" health and mortality data. And, according to an analysis of his data published in The British Journal of Cardiology last month, Dr Revill almost eradicated mortality from heart disease for patients aged under 70 on his patient list.
I began taking these about a year ago, my problem is they make my joints hurt mainly in my hands. I started...
Posted by An_258236
I began taking these about a year ago, my problem is they make my joints hurt mainly in my hands. I started on a 5mg dose then went up to 10mg, it made the pain worse so now I'm back to the 5mg which has lowered my numbers, but I continue to have the joint pains in my thumbs mainly. Anyone else experience this type of pain ?View Thread
I read that the brand of cholesterol medicine I take can cause a rise in sugar in your blood, and now, for the first time I have been told I am pre-diabetic. No one in my family has ever been diabetic. Could this be from my cholesterol medicine?View Thread
Doctors worrying about the safety of cholesterol-reducing statins are creating a misleading level of uncertainty that could lead to the loss of lives, according to one of the UK's leading medical academics.
Professor Sir Rory Collins, from Oxford University, said he believes GPs and the public are being made unjustifiably suspicious of the drug, creating a situation that has echoes of the MMR vaccine controversy.
"We have really good data from over 100,000 people that show that the statins are very well tolerated. There are only one or two well-documented [problematic> side effects."
Myopathy, or muscle weakness, occurred in one in 10,000 people, he said, and there was a small increase in diabetes.
Really sad and an eye opener for those that think cholesterol doesn't kill;
An 11-year-old schoolgirl who told friends 'Oh God I feel like I'm going to die, I love you all' before she collapsed and died, was suffering from a treatable hereditary disease.
Rianna Wingett was suffering from hypercholesterolaemia (FH) - where the body cannot filter out the bad cholesterol causing arteries to narrow.
This brought on a fatal heart attack after she ran two laps of her school's sports field in Hornchurch, Essex.
Initially it was thought she suffered from an undiagnosed heart condition but later it was discovered her cholesterol levels were dangerously high.
A post mortem examination revealed Rianna had extremely high cholesterol levels of 20 - 30mmol (millimoles per litre) - at 7.5mmol doctors normally put patients on medication because they are deemed to be at high risk of heart attacks.
Her arteries had been so badly clogged they were just the size of a pinhole and her heart was struggling to pump blood around her body.
I had my first heart attack in 2002, and have had two more since. I now have four stents, and have been on sinvastatin (80mgs) daily for 12 years. I have constant muscle pain and weakness, joint pain, memory loss, all the symptons we've heard about. My cholesterol levels have been in acceptable range, but I'm wondering if there's something else I can take without all the side effects. What would be effects of just stopping statin after all these years.?View Thread
A great paper from WHO concerning the MONICA trial findings after the fact;
Systematic reviews and large RCTs have also found that lowering cholesterol in people at high risk of ischemic coronary events substantially reduces the risk of CVD mortality and morbidity. One systematic review of primary and secondary prevention trials has reported that statins constitute the single most effective type of treatment for reducing fatal and non fatal myocardial infarctions and cardiovascular deaths.
The findings of this meta-analysis indicate that statins may be beneficial in preventing the occurrence of stroke in general. In particular, it may potentially reduce the incidence of fatal stroke and hemorrhagic stroke. However, caution must be exercised when using statins in patients with a history of renal transplantation, regular hemodialysis, TIA, or stroke. Further analyses based on data collected in multicentre, double-blind, placebo-controlled, randomized trials and stratified by primary diseases and dose—effect relationship are warranted to substantiate the findings of this meta-analysis.
Big change in the number of deaths from heart disease starting in 1997, lower cholesterol due to statin use included in list of reasons;
The American diet is better for the heart than it used to be, at least in some respects. But lower cholesterol levels also belong on the list of positive influences and along with them, statins. It's hard to beat a statin if the goal is lowering your LDL. If you take the pills as prescribed, LDL levels typically decrease by about 30%.
Overall, the mean age at death among statin users was 2 years older than among nonstatin users, despite statin users being at a higher risk of death. In conclusion, the results of this study have shown that using statins is a potent life-saving strategy. The benefit observed in this study is unique because almost 1/2 the patients were >70 years of age when statin therapy was initiated.
They then used data on blood pressure and total cholesterol for more than 38,000 patients taking part in the Melbourne Collaborative Cohort Study, to calculate the likelihood of developing cardiovascular disease and the advantages of preventive strategies.
On the basis of risk factors among participants in the Melbourne study, some 5390 new cases of cardiovascular disease and 710 related deaths would be expected over 10 years.
Almost one in four (24%) would be eligible for statin treatment under NICE guidelines. If half (4563) of these fully complied with statin treatment, an estimated 174 cases of cardiovascular disease and 70 deaths would be prevented.
Over 70,000 Canadians die every year from stroke and heart disease, while estimated mortality from statin myopathy is one in a million.
It's estimated that 30% of patients started on a statin will complain of soreness. In trials, an equal number complained of the same symptoms on placebo. Placebo is a dangerous drug! Hilarious
Statins are safer than aspirin, yet these life-saving drugs cause individuals a great deal of worry that's simply not justified. Statin therapy lowers the risk of a vascular event by a third with low-dose therapy and by up to 50% at high doses.
Its advice to health professionals said at least 450 deaths from heart attacks, stroke or vascular failure would be prevented for every 10,000 patients treated, if patients with a 20 per cent risk or more of suffering such a cardiovascular event over a 10-year period took statins for at least five years.
Non-industry-sponsored studies yielded greater efficacy estimates than industry-sponsored studies. Despite subgroup analyses by risks of bias, including financial COI information, optimal timing of outcome measurement, accounting for all animals, inclusion criteria, blinding, and randomization, efficacy estimates for nonindustry-sponsored studies remained significantly greater than industry-sponsored studies.
Do statin drugs really prevent heart attacks and save lives? How would anyone prove it?
Purely my opinion, but absolute proof statin drugs prevent heart attacks does not exist. The key word here being "Absolute"
The vast majority of cholesterol drug trials have used preventing events, mainly heart attack and stroke as endpoints. Not eradicating disease. So when we are dealing with preventing events, we are dealing with a whole different animal than fighting disease.
For ABSOLUTE proof a statin drug intervened and prevented a heart attack, we would have to know exactly WHO is destined to have a heart attack and WHEN.
For ABSOLUTE proof statin drugs save lives, we would have to know WHO is going to die and WHEN.
By giving the drug, if the inevitable event is aborted, we can say with confidence the drug prevented a heart attack and saved a life.
Of course its impossible. Nobody knows who is destined to suffer an event, or when they are "scheduled" to die, so its impossible to measure the ABSOLUTE efficiency of any drug in preventing these events in any individual.
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