the impact of 5 years of pravastatin therapy continued over 20 years with 13% and 27% reductions respectively in total and CHD mortality (both P<0.001) over the entire period heart failure hospitalisations were 31% lower in the statin treated group (P<0.0001)
total length of stay (days) across all CVD admissions was reduced by 25% in the statin treated subjects (P<0.0001)
With p values like that not much possibility of the results being by chance.
Now this was only reported at the AHA meeting and the full report has not been published yet. But whenever I have seen the details of a large RTC like this one the parameters of the 2 arms are usually fairly close. So I don'tView Thread
A massive study of more than 113,000 people published Wednesday by Boston researchers found that people with a flawed gene have modestly lower levels of "bad" LDL cholesterol and half the risk of heart disease than those with the normal, functioning gene. "My best guess is the reason we see a much larger difference in disease risk ... is the genetics is a reflection of lifelong differences," said Dr. Sekar Kathiresan, director of preventive cardiology at Massachusetts General Hospital, who led the work. "The cumulative effect of slightly lower LDL over many years probably leads to a greater reduction in risk." The drug, called ezetimibe, works by disrupting a protein called NPC1L1, which is involved in the absorption of cholesterol in the gut. The rare gene mutations detected in the study also inactivate the protein.View Thread
Soluble fibers attract water and form a gel, which slows down digestion. Soluble fiber delays the emptying of your stomach and makes you feel full, which helps control weight. Slower stomach emptying may also affect blood sugar levels and have a beneficial effect on insulin sensitivity, which may help control diabetes. Soluble fibers can also help lower LDL ("bad") blood cholesterol by interfering with the absorption of dietary cholesterol.
It consisted of several links to medical sites that where appropriate to the posters question.
I got an error on a link to the MESA study site that include the initials of National Hockey Leaque as part of the link. It kept giving me an error message that the message violated the WebMD terms and highlighted those 3 letters.
I then deleted that link and posted the rest of the message. The message showed up at that time, but was gone the next day.
I them posted a completely separate message using "Report this" that contained the problem link and asked what was going on.
There was no other method given ask the question.
I have not had a response to that comment either.View Thread
"The published studies demonstrate a high sensitivity of CAC for the presence of coronary artery disease but a lower specificity for obstructive CAD depending on the magnitude of the CAC. Several large clinical trials found clear, incremental predictive value of CAC over the Framingham risk score when used in asymptomatic patients. Based on multiple observational studies, patients with increased plaque burdens (increased CAC) are approximately ten times more likely to suffer a cardiac event over the next 3—5 years. Coronary calcium scores have outperformed conventional risk factors, highly sensitive C-reactive protein (CRP) and carotid intima media thickness (IMT) as a predictor of cardiovascular events."
I did not have time to read the whole article, but it appears useful.