The endpoint must make sense in the ability to gather and measure outcomes within a reasonable limit.
Using surrogate endpoints like cardiac events is done to assure that a large amount of data can be collected that can reliably prove the correlation of the outcome. Without them, the results of overcoming all the issues above would greatly limit the quality and amount of data that can be collected to prove an outcome.
The purpose of a study is to collect data in sufficient quantity and quality show a correlation to an endpoint. The endpoint must be definable and of a consistent nature among participants. You may be able to use eradication of a virus like Ebola as an endpoint and in fact they do as you stated in many, many studies. Not the case for CAD as it has different manifestations and rates of progression. Cardiac event is the logical endpoint.View Thread
The controversial 2013 American Heart Association/American College of Cardiology guideline on the assessment of cardiovascular risk matches statin use to patients' total plaque burden better than did its predecessor, the 2001 National Cholesterol Education Program Adult Treatment Panel III recommendation, according to a retrospective study published online Aug. 25 in the Journal of the American College of Cardiology.
It is done for me, your Ebola comment was the perfect ending.
Bobby, I answered your question about endpoints and I've moved on, something you should learn to do as well. What I can't tolerate is another discussion about the pharmaceutical industry with you, that's all.
I'm sure some one else will come along and join in, pick their brain.View Thread
Under NCEP guidelines, 59% of patients with 50% or more stenosis of the left main coronary artery identified by CT angiogram, and 40% of patients with 50% or more stenosis of other branches would not have been prescribed a statin. The comparable results for the GACR were 19% and 10%, respectively, they wrote online in the Journal of the American College of Cardiology.
Sorry Bobby, I understand what the problem is now. Also, please understand that I am not bothered, I have to explain my positions and findings to data management boards, fellow research consortiums and funding partners. Nothing that happens on an Internet website will cause me to become bothered.
As I said, I understand why we can't connect now. The Ebola comparison clears up a lot.View Thread