For every 10 mg/dL increase in high density lipoprotein (HDL) or "good" cholesterol, among men with abnormal HDL (below the desirable value of 40 mg/dL), the risk for prostate cancer recurrence was lowered by 39 percent. Of the 843 men studied, 293 had a biochemical recurrence, defined as rising PSA levels after prostate cancer treatment, indicating the recurrence of the patient's prostate cancer.
What is important about this is we have never really understood how cancer spreads the way it does. It seems that some people are affected with more aggressive cancers than other so the research needs to be done to understand why.
What has been clearly shown is many types of cancers use the blood stream to spread cancer, more specifically cholesterol. Many cancers need the synthesis of cholesterol as a mechanism to spread.
Most people will welcome and celebrate a discovery like this while others will look to conspiracies about this all being about making money. Some will move forward, some will stay fast in the beliefs they're bound by.
I for one welcome medical advances. FYI, on a personal note, congrats to my nephew for achieving his PhD in chemical engineering, well done!View Thread
The Pitt researchers noted when a tumor metastasizes, it spreads cancer cells through the body using the blood stream. Cancer cells require the synthesis of cholesterol for that process. Statins, may block a key step in that process.
Cancer cells require the synthesis of cholesterol and cholesterol precursor molecules to reprogram themselves from an adherent, or "epithelial" state, to a mobile, or "mesenchymal" state, in order to leave or "shed" from the primary tumor and recolonize elsewhere in the body. Statins, which are routinely used to lower lipid levels, could potentially block cancer cell spread by inhibiting an enzyme that catalyzes a key step in the cholesterol synthesis process, Dr. Oltvai said.
Scientists say that statins, the most widely-prescribed drugs in the UK, can stop cancer from spreading around the body. This is important because most of the 160,000 Britons who killed by cancer each year die after it spreads to other organs.
With some statins costing under 3p a tablet, University of Pittsburgh researchers said that the pills 'appear to be a promising, cost-effective' way of reducing cancer spread.
The INTERACT trial involved 303 patients who had been prescribed blood pressure and/or cholesterol lowering medication. Patients were divided randomly into two groups; a 'text message' group who received periodic text messages and a 'no text' group who received no text messages.
The 'text message' group received texts every day for two weeks, alternate days for two weeks and then weekly for 6 months, asking if they had taken their medication that day. Patients who had not, or did not reply, were telephoned and offered help.
A new study published in the Journal of the American Heart Association found that a daily snack of 1.5 ounces of almonds instead of a high-carbohydrate muffin, eaten as part of an overall healthy diet, improved a number of heart disease risk factors in study participants.
In addition to significantly improving LDL and total cholesterol, snacking on almonds instead of muffins also reduced central adiposity (belly fat), a well-established heart disease risk factor.
Well here's an interesting slant, people with a positive attitude have lower cholesterol;
Optimists had significantly better blood sugar and total cholesterol levels than their counterparts. They also were more physically active, had healthier body mass indexes and were less likely to smoke, according to a paper on the research that appears in the January/February 2015 issue of Health Behavior and Policy Review.
People who stay away from drama, conspiracies and worry do better in life and in their health, go figure!
Another article showing the link between cholesterol and breast cancer;
To reach their findings, the investigators analyzed information from the ACALM clinical database between 2000 and 2013, which included more than 1 million patients.
Of the 664,159 women in the database, 22,938 had hyperlipidemia, or high cholesterol, and 9,312 had breast cancer. The team found that 530 of the women who had high cholesterol developed breast cancer.
The data shows a very real link. High cholesterol helps spread many cancers.
The evidence is finally being published. Many of us already knew this from independent review of the data. Statins simply do not impair cognitive function and a movement is out to have the mention of "a possible link" removed from statin warnings;
Subsequent reviews of available research have cast doubts on the cautionary stance taken by the FDA. Ott's and colleagues set out to do a more comprehensive analysis using well-studied analysis methods. They scrutinized the data of 25 relevant randomized clinical trials that investigated a possible link between statin therapy and mental ability. Combined, these studies included the test results of 46,836 patients. Ott and his colleagues also contrasted and combined the results of 14 of these studies through a meta-analysis, which in total included 27,643 participants.
The review found no significant effect of statin use on the mental capacity of either people with normal brain functioning or even those with Alzheimers' disease. The results suggest that the FDA's statin warning should be re-evaluated. Ott also believes there is a need to investigate the reasons behind the differences in the review results and the initial reports on which the FDA warning was based. It could be that some of the mental changes that were reported in the case studies were the result of overdosing with statins.
"We found no significant effects of statin treatment on cognition," concludes Ott. "Given these results, it is questionable whether the FDA class warning about potential cognitive adverse effects of statins is still warranted.."