Well written paper, from a group of dieticians no less;
Beyond CVD Prevention and Treatment Cancer Epidemiological studies have strongly suggested that statins may be useful in treating and preventing certain cancers, particularly prostate cancer, a significant cause of death among men in the United States. Statins may work by lowering serum levels of prostate-specific antigens.
Neurological Damage Another growing area of scientific interest in statin drugs is their potential to treat neurodegenerative conditions such as Alzheimer's disease, multiple sclerosis, and Parkinson's disease. Further research is needed to validate this potential function of statin drugs and to pinpoint the precise mechanism of action.
In the January 2010 issue of Neurotherapeutics, researchers at Duke University School of Medicine addressed statins' neuroprotective potential, referring to preclinical studies showing a significant benefit from statins in treating traumatic brain injury and other related neurological conditions such as intracerebral hemorrhage and subarachnoid hemorrhage. The authors reported that previous studies had defined several mechanisms by which statins provided benefits after traumatic brain injury.
Inflammatory Disease Using statins to treat inflammatory disease may also be on the horizon.In the December 2010 issue of Aging, Japanese researchers Yudoh and Karasawa published their study examining the anti-inflammatory potential of statin drugs, focusing on their ability to prevent catabolic stress-induced chondrocyte aging and degeneration of articular cartilage in individuals with osteoarthritis. Based on their finding, they concluded that statin medications are a potentially effective therapeutic agent for protecting articular cartilage against the progression of osteoarthritis.
Liver Disease Ongoing research is demonstrating statin drugs' potential to prevent and treat liver disease. As published in the January issue of the American Journal of Gastroenterology, Foster and colleagues analyzed 1,005 men and women (as part of the St. Francis Heart Study) to determine whether statin therapy may be an effective treatment option for patients with nonalcoholic fatty liver disease (NAFLD). They concluded that the use of atorvastatin in combination with vitamins C and E is effective for reducing the risk of hepatic steatosis by 71% in healthy individuals with NAFLD at baseline following four years of therapy.
Statins' Risks and Benefits According to the Mayo Clinic, potential risks of long-term statin administration range from less serious side effects such as nausea, diarrhea, and muscle pain to more severe effects such as liver damage.
Hudson says higher doses of statin drugs may cause myalgia and muscle pain but pose only a small risk of liver injury. "A fair number of patients experience side effects like myalgia, especially with higher doses. Some of the other more serious concerns, like liver disease, have been greatly overstated. Statins are safer than most OTC [over-the-counter> meds like antacid or cold medicine," he says.
"Some people are calling statins, a class of medications that lower bad (LDL) cholesterol, the greatest drug breakthrough since Penicillin. Others though, are cautioning about the overuse of these drugs and potential side effects.
With new guidelines recommending an increase in the use of statins to treat elevated cholesterol, what should patients think if their doctor recommends that they start taking a statin?
While an argument can be made that some medications are probably being over-prescribed, Dr. Khetan, Dr. Wiley and Dr. Schussler all agree that this is not the case with statins.
In fact, all three cite statins as one of the primary drivers of the decrease in incidence of heart attack and lowering the risk of heart disease."
For patients with coronary atheroma, high-intensity statin treatment is associated with greater regression in women than men, according to a study published online Sept. 17 in JACC: Cardiovascular Imaging.
The use of statins by persons with type 2 diabetes has been associated with lower risks of retinopathy, neuropathy, and nephropathy, in research published in The Lancet Diabetes & Endocrinology.
"Since high levels of blood glucose, the hallmark of diabetes, are linked with microvascular disease, and since statins are suspected of raising glucose levels, we tested the hypothesis that individuals taking a statin before a diagnosis of diabetes might be at increased risk of developing microvascular complications," explained study author BÃ¸rge G. Nordestgaard, MD, in a press release from The Lancet. "Surprisingly, the results showed that statins decreased rather than increased risk of these complications."
The occurrence of AF was reduced 35% in statins therapy group compared to that in non-statins group (95% confident interval: 0.55-0.77, P<0.0001), and the effect of statins therapy seemed more beneficial for new-onset AF (RR=0.59, 95%CI: 0.48-0.73, p=0.096) than secondary prevention of AF (RR=0.70, 95%CI: 0.43-1.14, p=0.085). There was no publication bias according to the Begg's and Egger's test (Begg, p=0.71; Egger, p=0.73).
Statin users had a 28% reduction in the rate of CRC-specific mortality compared with nonusers (hazard ratio [HR>, 0.72; 95% confidence interval [CI>, 0.64-0.81). Patients who used statins for less than one year had a 21% reduction in their rate of CRC-specific mortality (HR, 0.79; 95% CI, 0.68-0.93) and those who used statins for more than a year showed a 35% reduction in cancer-related mortality (HR, 0.65; 95% CI, 0.56-0.77).
You hit it on the head, high cholesterol with a genetic predisposal can only be controlled with meds. It's unfortunate, but a reality.
However, there are those that will post and say cholesterol is not a bad thing, even though every piece of evidence points to the contrary. Some people are jus not able to see past their personal beliefs and see the entire picture.
Statins can only help, but if you have issues see your doctor.View Thread