..........and from the introduction to this same CC paper, it says this:
'Statins have proven efficacy in preventing heart attacks and death,1 and they are the most widely prescribed drugs worldwide. Nevertheless, they remain underused, with only 50% of those who would benefit from being on a statin receiving one.2 ,3 In addition, at least 25% of adults who start taking statins stop taking them by 6 months, and up to 60% stop by 2 years.4 '
My basic question for iride is this, how does valid statistical analysis miss something this obvious?
..............and this is what is says, and I am copying all of it's bullet point 'findings':
'Findings of the PRIMO study are representative of typical statin-induced symptoms that we see in our clinic.20
Most patients did not identify a trigger, but the 40% who did had engaged in unusual physical exertion or had received a new drug in addition to the statin.
Heaviness, stiffness, or cramps predominated in 70%, with only a quarter noting weakness and another quarter suffering myalgias during exercise. Pain was diffuse in 60% and more common in the lower extremities than the upper extremities.
Physically active patients were more likely to suffer muscle symptoms than sedentary patients, echoing the observation by Sinzinger and O'Grady that athletes are especially intolerant of lipid-lowering therapy.41
Patients who have had muscle complaints with other drug therapies such as bisphosphonates, 42 raloxifene (Evista),43 or diuretics may be having the same provocation of an underlying muscle predisposition by the statin.
A personal or family history of muscle complaints predisposed patients to statin-induced myopathy.20
Finally, we have repeatedly found that when dyspnea and fatigue are associated with the muscle complaint, they are more likely to be caused by statins.44 ' How did, or how can, valid statiscal data analysis miss side effects this obvious?View Thread
iride, how did the original statistical data miss a side effect problem with myopathy, where 25% of patients show this problem within 6 months, and 60% within 2 years, as quoted in this CC article, with referenced footnotes and extra data?
I will await your response..........perhaps it is you that should be apologizing for the original data.View Thread
Then why did not the trials in the case of these statin drugs, find the muscle problems? Why did it take clinical experience with millions of people on these drugs, to find the myopathy problems? Why did medical people continue to deny the existence of these problems, when these drugs were so widely prescribed? The Cleveland Clinic article above tries to explain why this happened, but does not come close to a rational explanation. Here is a bullet point, once again, from the CC article: 'In addition, at least 25% of adults who start taking statins stop taking them by 6 months, and up to 60% stop by 2 years.4 '
Why was this not discovered in the original trials for these drugs? With a problem level of this size, why was not this discovered much earlier? The medical research work is out there now, and it still is not widely disseminated among family docs, and it still is not included in the standard of care. Why is this so?View Thread
iride6606, I have a good friend PhD statistican who worked for Big Pharma for awhile, and could not endure the statistical analytical compromises needed to do your job. I have great respect for my friend, as he walked away from doing what you are doing. Doing repeated trials until the requested data is obtained, is apparently something you have no problem with, but my friend thought that process flawed.View Thread
'Perhaps there needs to be more responsibility on both sides. Both Patients and Doctors need to be more educated on the potential consequences of blocking the mevalonate pathway.'
I can see both Bobby and Iride are health care professionals, and while I do respect that fact, I respectfully disagree with the idea of making the patient responsible. I feel I have the capability to actually do that, if I have access to the facts, but sadly, 70-90% of patients do not have that capability and are solely only listening to their docs. The concept of making the patient responsible takes the doc off the hook, and I understand while that idea is one you are both comfortable with, but there is one BIG thing standing in the way, and that is the Standard of Care. Let me ask you some big questions. Are you going to give the patient a voice in setting the Standard of Care? Are you going to adjust the standard of care so that there is enough flexibility in those standards, that the patient actually has a voice in these decisions? If you don't, then the patient will never have a real voice in these decisions. Just a thought!View Thread
'Maybe the statin is NOT responsible, could that be possible?.'
Perhaps an update might help with that thought. The muscle pain in my left quad is improving daily, and I can finally again lay on my left side at night while trying to sleep. Last dose of Pravastatin was 11/3/12, and today is 12/15/12. My shoulder is still sore, but it seems to me that the progression is in the same pathway as the onset, which might mean that the shoulder will be the last to wash out. There is no doubt in my mind that it was the Pravastatin at this point. View Thread