For me it got to a point that medication wasn't helping my depression. The depression was so bad that I had to be hospitalized for my safety.
I've had over 50 ECT treatments and I would do it again if I had to.
Now I'm looking into TMS, where your not asleep, your given no medication, there is no pain, no memory loss, you just have to have the procedures daily for 6 weeks.
If you have the TMS procedure and it works then you won't have to take medication anymore and right now I take 11 different medications for one thing or another.