Definition: Glucose-6-phosphate dehydrogenase (G6PD) is an important protein (enzyme) that helps blood cells use sugars to produce energy. Normal amounts of G6PD protect red blood cells from certain drugs or chemicals. Current Facts
What is G6PD Deficiency? G6PD deficiency is an abnormally low level of the G6PD protein in the blood cells. Some people refer to this condition as favism, because eating fava beans can trigger symptoms in a person with G6PD deficiency. In people with this deficiency, exposure to certain drugs, foods, and chemicals can result in damage or destruction of red blood cells. Destruction of red blood cells can cause serious illness.
My DH doctor told him all oral medications for diabetes sulfur or not can cause his body to destroy his red blood cells.
He has tried two different classes both started a rapid destruction of red blood cells. It seems him only alternative is to take insulin. He is trying with food and exercise right now,but his doctor ordered a full genetic test to determine his degree of G6PD deficiency to find out if there is an oral medication that is suitable for him.
Well, I definitely don't believe everything I read online, nor do I believe everything a doctor or pharmacist tells me. I use it at tools in conjunction with my family to determine what is best for us. In the case of Metformin there are only a few studies published in medical journals in the world. I have read several European and a few Asian ( although when it comes to anything medical concerning G6PD deficiency I trust Europeans the most, they are simply more advanced in medicine- just my personal opinion and experience. My son was diagnosed with G6PD deficiency after a routine doctors appointment in Europe ,my husband was diagnosed years later in the US and not until I printed material from the Internet and showed his doctor, for him to even test him for it. I have yet to meet a doctor in the US who knew what G6PD deficiency is, much less what kind of meds they can not take. When my son had to have an operation I had to sit with his anesthesiologist and tell him that he can not use conventional anesthesia on him because of this genetic defect. So I am not surprised that a pharmacist does not know or believe that Metformin is "classified" in the sulfonylurea agent category. I now know that my husband reacts to Metformin and we believe it is because it is a sulfonylurea agent drug , I am not a doctor just an RN and I can not give medical advise just share my personal experience.View Thread
Treatment of patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency with sulfonylurea agents can lead to hemolytic anemia. Because Glyburide and Metformin hydrochloride belongs to the class of sulfonylurea agents, caution should be used in patients with G6PD deficiency and a non-sulfonylurea alternative should be considered. In postmarketing reports, hemolytic anemia has also been reported in patients who did not have known G6PD deficiency. and according to G6PDdeficiency.org
View G6PD Deficiency Contraindicated Substance Details Metformin FormulaC4H11N5Chemical Name1-carbamimidamido-N,N-dimethylmethanimidamideCategoryAntidiabeticHemolysis RiskHigh - AllThose AffectedAllG6PD InformationChemical InformationNotesReports suggest that Metformin has caused hemilysis in people without known G6PDD.
my DH took Metformin and had the beginning stages of Hemilysis. Nothing else could have caused itView Thread
can someone explain to my how blood sugar levels rise after exercise? My DH bg was 103 before and 210 after 30min of exercise . He was weight lifting , in contrast 30min on an exercise bike brought his bg down from 150 to 100. Does that mean he can never work out with weights again? Or anything with minimal resistance , pushing a lawnmower for 30min also elevates his bg by ~ 100. His endo and dietician appointment is still weeks away. Does anyone have any experience with this? Thanks for your help!View Thread
Thanks for your response. Recipes are not so much the problem, I have changed our regular meals to more veggies and whole grain , which seams to work well for him and his BG. I am looking for ideas for food on the go- he works night shift and has no ability to heat up anything and eating salads, fruit and sandwiches every night gets boring quick. I keep looking.View Thread
Appointment for my DH with the Dietitian is still weeks away.In the meantime I am looking for recommendations for cook books or links to develop a diet for diabetes. My husband cannot eat any beans, peanuts, soy products, limited dairy, and some green vegetables. Before his diagnosis that was no big problem but now it limits his healthy food choices enormously since a lot of foods that a diabetic can and should eat, he can not. Any input would be apreciatedView Thread
Somehow it comes across everywhere that after one is diagnosed with diabetes blood glucose should be down to "normal" immediately! it did not get to those levels overnight so why should it be down after 2 days?! My husband no longer takes Metformin ( he is G6PD deficient and this medication can destroy his red blood cells and be deadly - in layman's terms- that is where his symptoms came from ). He does take a different one and so far no side effects. His readings are continuing to go lower with diet and exercise, over the last 1 week he went from 560 to 159 today 2 h after eating a 65 carb wholegrain meal. Off course he levels are still all over the place but no higher than 250, to complicate matters he works permanent night shift so I do expect it to take a few months to get into normal ranges. One day at a time View Thread
My husband has just been diagnosed with Type 2 diabetis.
He is very fit, muscular, a regular" health buff ". he exercises 5 times a week, for the last 30 years, eats very healthy. He is also G6PD deficient, his endo said that is more likely than not the reason why he developed diabetes.View Thread