After 4 days on Savella starter pack I was TOXIC pain dr said switch from Cymbalta to Savella maybe help my fibro shoulder and back pain that Cymbalta had worked for years for my neuropathy of feet and some of my fibro pain with no side effects other than mild blood ppressure increase BY DAY 3 of Savella I was moody, irritable, angry, sick with a sedated effect, nausea, dizzy and by DAY 4 I woke up with metal taste and later began PUKING My mood swings were new and obvious-very emotional- crying in front of strangers- all new for me and the sedation,dizzy,metal taste and puke all extreme I have fibro and RA and back damage so pain is all day every day even with pain meds but I do manage to enjoy life and function ok but not able to work so I was desperate to improve my energy and attitude But Savella was a mistake for me and I have tried Lyrica with 25 pound gain in 6 months and couldnt stay awake SO for my system Cymbalta gives moderate result with least side effects Note I also had the strange dreams and sleep issues immediately with Savella - an all around 4 day bad experience, it is now day 6 with 2 days not taking it and I still feel weak, nausea and yukk taste in mouth As mentioned previously in this forum PLEASE TALK TO YOUR Doctor ABOVE any advice given here by fellow sufferers AND in my experience- carefully consider your doctors advice and if he or she is the right dr for you and if they do understand your body and your disease The pain dr who handed me the Savella sample pack barely knew me- it was my first visit and I feel he should have waited a few months before changing my medications That is what my RA doctor does- careful cautious consideration God Bless each of you I understand the toll daily pain and fatigue takes on us and our families.View Thread