Gimpy, I have suffered with excruciating pain episodes for the last 2 1/2 yrs. after a full knee replacement. I have undergone a plethera of tests to ascertain my body's state of health including gene testing to determine the health of my immune system. I have been found to be "positive" for one of the indicators of Lyme Disease (which can mimmick over 200 diseases) and, in more recent testing, (MELISA test) I was found to be sensitive to Cadmium and hypersensitive to Nickel. My doctor is currently working to understand what that means... My local allergy clinic just told me today that hypersensitive is the same as allergic. So you can do allergy testing and you can also do a MELISA test (not FDA approved). There are two different tests that check for several different metals each and your doctor should be able to help you with that choice. Don't forget that there is probably some type of plastic in your body as well and it might be worth finding out if you react to that as well. I feel your pain, NO pun, and wish you the very best.