I was skeptical about the clinical trial results for Benlysta but agreed to try the drug anyway as nothing else seemed to be working. I've now been on Benlysta for 15 months and am pleasantly surprised by the results and the lack of side effects! My skin is almost completely clear, I'm less anemic, have way more energy...and my ANA has declined to less than half my pre-treatment levels. As some of the other responders have noted, I feel best the 2nd and 3rd weeks after the treatment. For the first week I usually have slight nausea and/or diarrhea. This was worse for the first few treatments but hardly noticeable now. For the 4th week, I usually start to feel more tired and achy as I was before the treatments. Yes, I may have some unwanted/unknown side effect in a few years (hopefully not the 3 heads someone mentioned) but in the meantime, Benlysta has allowed me to resume my life almost like a normal person.View Thread