Given your family history , you probably should get tested. The anemia you describe could also be autoimmune related . Don't be surprised if the test comes back negative or inconclusive. It can take years to get a proper diagnosis. The best time to get tested is when you are actually having symptoms. I would suggest you see a rheumatologist to get the testing done. They are the ones that specialize in lupus.
You might want to keep a journal of your symptoms. Track your temperature, BP, weather, what you eat and drink, along with any other symptoms you have on a daily basis. Take pictures of any visible symptoms like selling, rashes etc The reason being, you will be able to show the doctor even if they symptom has disappeared by the time of your appointment.
There is no single blood test for diagnosing lupus. Systemic Lupus Erythematosis (SLE) is diagnosed using 11 criteria. IF you have 4 out of 11 it is likely you have lupus.
Face rash, which doctors call a malar rash, that is butterfly shaped and covers the bridge of the nose and spreads across the cheeks
Scaly rash, called a discoid rash, which appears as raised, scaly patches
Sun-related rash, which appears after exposure to sunlight
Mouth sores, which are usually painless
Joint pain and swelling that occurs in two or more joints
Swelling of the linings around the lungs or the heart
A neurological disorder, such as seizures or psychosis
Low blood counts, such as low red blood count, low platelet count (thrombocytopenia), or a low white cell count (leukopenia)
Positive antinuclear antibody tests, which indicate that you may have an autoimmune disease
Other positive blood tests that may indicate an autoimmune disease, such as a positive double-stranded anti-DNA test, positive anti-Sm test, positive anti-phospholipid antibody test or false-positive syphilis test
If she has been on prednisone or any other steroid, it could be that she is getting cataracts. she should go to an opthamologist for a thorough eye exam. As for the boney structure under her skin, depending on the location, it could be cyst which should also be seen by a doctor.
Lupus and RA are both autoimmune diseases. Many people have both lupus and RA. One is not responsible for causing the other. Many of the same meds are used to treat both diseases (like Prednisone, Methotrexate) So I would guess that if these meds are used for one it will also help the other.
The eye problems related to plaquenil usually doesn't have any visible symptoms, which is why you need to see an opthamologist every 6 months for visual field testing and a full eye exam. They can detect any problem in your retina before they become permanent.