So, I may have systemic Lupus (SLE) and I have Bipolar. I have had no treatment success with over 25 different medications used for Bipolar symptoms (like depression). The Dr's have been trying Atypical Anti Psychotics recently and they seem to make my mood drastically better. The problem is they cause painful pitting edema within two weeks of starting the med. The edema progressively worsens if I stay on the med. If I try a re-start of the med I swell within two days. Does anyone know if there is a connection? What can I do? ThanksView Thread