I also have secondary progressive, I apparently made the fun transition from RRMS to Secondary Progressive in early 2013. I have not taken any disease modifiying drugs while having RRMS because I did not know I had MS. I was diagnosed with MS in May of 2013 due to my symptoms escalating and progressing in the January/February timeframe of this year. My Neurologist does not feel I am a candidate for disease modifying drugs as I have moved out of the Relapsing phase of the disease. I hate to take these types of drugs if the benefit doesnt outweigh the risk, but at the same time I am worried that not taking a disease modifying drug will cause me to progress faster and that would be bad. I am aslo positive for the JC virus so I am not sure Tysabri would be safe for me. Any thoughts would be greatly appreciated.