One of the causes of atrophy is an excessive amount of apoptosis of cells. Apoptosis is a form of cell death. I suspect apoptosis is the main cause of brain atrophy in the case of chronic and/or age related disorders.
Low doses of diphenhydramine (Benadryl) inhibit apoptosis!
There is also reason to believe that low dose Benadryl is an effective treatment for MS in general.
you need to learn about the "mito cocktail" of vitamins and supplements. There are some resources but everyone's cocktail is a bit different so there is a lot of trial and error. Google "mito cocktail" and you'll see
read here about low dose Benadryl and statin damage:
"Summary Researchers in Dr. Lawrence Steinman's laboratory at Stanford have developed a new strategy for treating or preventing autoimmune diseases with antihistamines. Using the EAE mouse model for multiple sclerosis (MS), the inventors have shown that the disease course and severity can be ameliorated with daily administration of antihistamine."
the dose range is 1 mg per 13.6 kg (30 lbs) to 22.6 kg (50 lbs) of body weight at meal times and just before going to bed. A dose within that range can be accomplished with 1/4 of a children's tablet afor a dose of 3.125 mg or 1/4 of an adult tablet for a 6.25 mg dose or a measured amount of the children's liquid for 2.5 mg per ml.
The only contra indication is "sodium channelopathy" (rare) and the symptom is rapidly increasing fatigue over the first 1 to 3 days. If this occurs she should stop the med (should recover in 1 to 2 days) and report the likelihood of a sodium channelopathy to her doctor.
there are alternatives that are not as effective but are also not sodium channel blockers so come back here if that happens.
Like MS, LHON is rooted in mitochondrial disorders and there is, by far, enough variability in the presentations of inherited forms of mito (in the same family) that your case would not be extraordinary.