"Summary Researchers in Dr. Lawrence Steinman's laboratory at Stanford have developed a new strategy for treating or preventing autoimmune diseases with antihistamines. Using the EAE mouse model for multiple sclerosis (MS), the inventors have shown that the disease course and severity can be ameliorated with daily administration of antihistamine."
the dose range is 1 mg per 13.6 kg (30 lbs) to 22.6 kg (50 lbs) of body weight at meal times and just before going to bed. A dose within that range can be accomplished with 1/4 of a children's tablet afor a dose of 3.125 mg or 1/4 of an adult tablet for a 6.25 mg dose or a measured amount of the children's liquid for 2.5 mg per ml.
The only contra indication is "sodium channelopathy" (rare) and the symptom is rapidly increasing fatigue over the first 1 to 3 days. If this occurs she should stop the med (should recover in 1 to 2 days) and report the likelihood of a sodium channelopathy to her doctor.
there are alternatives that are not as effective but are also not sodium channel blockers so come back here if that happens.
Like MS, LHON is rooted in mitochondrial disorders and there is, by far, enough variability in the presentations of inherited forms of mito (in the same family) that your case would not be extraordinary.
First, I believe your experiences and those with gulf war syndrome and those with ptsd are all related. In short they are all based on acquired metabolic disorders, specifically acquired mitochondrial dysfunctions. Even you MS.
Second, I have an acquired mitochondrial dysfunction and in my quest to, at least, stop my decline I literally stumbled onto something that REALLY helped.
In my quest to understand what I was seeing I found this:
Researchers in Dr. Lawrence Steinman's laboratory at Stanford have developed a new strategy for treating or preventing autoimmune diseases with antihistamines. Using the EAE mouse model for multiple sclerosis (MS), the inventors have shown that the disease course and severity can be ameliorated with daily administration of antihistamine.
From the abstract: 1. It is shown that a number of antihistamine drugs which prevent liver injury inhibit mitochondrial swelling at concentrations at which they do not affect electron transport or oxidative phosphorylation.
I found that low doses of Benadryl (diphenhydramine) through out the day proved to be the most effective of the treatments that help me with my condition.
Try 1 mg per 30 to 50 lbs body weight. Most people can get a dose within that range by using 1/4 of the adult tablet for a dose of 6.25 mg or 1/4 of the children's tablet for a dose of 3.125 mg. I use 2 ml of the children's liquid (diluted) for a dose of 5 mg.
take that 4 times per day at meal and bed times. simple as that!
The only adverse reaction occurred in an individual with a sodium channelopathy (rare) He experienced increasing fatigue after 3 days and returned to his normal level after 48 hours.
Try this, you should see a burst of improvement within 3 days, a week at most!
I have some feedback from an MS'er if you would like. Let me know.