I've been on Enbrel now for some time. For me, Enbrel injections were extremely painful. I discovered that they are painful for two reasons. The needles are thick and blunt and cause pain upon entry, and the medication itself is very painful when it enters your body so quickly. After switching from the auto injector to the prefilled syringe I discovered I could control the flow of medication and thereby greatly reduce the pain. I often take up to 2 minutes to complete the injection. Another added benefit is that if you inject yourself and find that you hit a nerve, you can remove the syringe and poke yourself somewhere else.
I have also discovered that the the needles used on these syringes are fat and blunt. They hurt. I have been using Becton Dickenson 1mL, 12.7mm, 30gauge insulin syringes. I remove the the plunger, place it in it's sanitary cap, inject the prefilled syringe into the barrel of the BD syringe, and barely place the plunger back on the BD syringe, being careful not to squeeze it out. Invert the BD syringe and tap the barrel to get the air up so you can squeeze the air out. The sharp, 30gauge syringe is absolutely painless. Half the time I don't even feel it.View Thread