Hi Periwinkle -- Sorry to hear Forteo didn't improve your BMD. However, please remember the notion of "quality versus quantity". Forteo has been shown to improve bone integrity among many. I've heard several accounts of people sustaining serious falls without a break thanks to the effects of the drug. Best wishes to you... megmo84View Thread
Hi Bonebabe - Does the immunosuppresive risks of Prolia concern you or the medical staff at your facility? I'm eager to start Prolia, but am wondering if a bisphosphonate might be a safer approach. Prolia is relatively new, while bisphosphonates have received more research.
What is the accuracy of CT scans in diagnosing vertebral fractures?
Dull back pain recently sent me to the ER in fear that I had fractured. Fortunately, the CT scan showed no fracture. The pain was short-lived and attributed to a pulled muscle. Nevertheless, the experience has left me rattled. Knowing for sure that my CT results were correct would be a great comfort.View Thread
Bonebabe - You talk frequently about breaking the struts within the vertabrae. How does one differentiate the positive effects of weight bearing exercise from other dangerous movements? Are you implying speed-walking, ellipticals, strength-training, etcetera may eventually wear down these struts? I've read and understand the NOF exercise recommendations.View Thread
I've often heard Prolia (denosomab) thrown around as yet another drug for osteoporosis. However, I never knew its mechanism of action and how it may benefit estrogen deficient women until now.
A brief summary: In normal bone physiology, estradiol causes osteoblasts to produce osteoprotegerin (OPG), which binds and neutralizes RANK ligand, a contributor to bone resportion. Similarly, Prolia targets RANK ligand, thereby inhibiting osteoclast activity. Some reports suggest that unlike bisphosphonates, Prolia may actually help build bone rather than simply stopping its destruction.
Could this be a viable option for a follow-up medication to Forteo?View Thread