I had my first Prolia injection 10 days ago. In approximately five days, my legs felt slightly started to ache. Each day the discomfort has increased and I'm finding it increasingly difficult to get comfortable in any position. I will check with my doctor tomorrow but have to reconsider use dependent upon how long this discomfort lasts and whether it increases or decreases over time. I will update my progress so others can make an informed decision over exposing themselves to something with so many side effects that may cause them problems for six months.View Thread