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Parkinson's Disease Community

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Mark A Stacy, MD

DUKE MEDICINE

Joined: 02/03/2010

Expert Profile:

Mark Stacy, MD, is the Director of the Duke Movement Disorders Clinic, Professor of Medicine (Neurology) and Vice Dean for Clinical Research at Duke University School of Medicine.

Mark Stacy's clinical and research interests include Parkinson's disease, motor and non-motor symptoms of wearing off, and pathological gambling and other impulse-control disorders.

His previous experience includes serving as director of the Muhammad Ali Parkinson Research Center at the Barrow Neurological Institute in Phoenix and director of the Parkinson's Disease Clinic and Movement Disorders Center at the University of Missouri. In addition to his current clinical and leadership roles at Duke, he serves as advisor and consultant on numerous national and community committees, including WE MOVE, the Parkinson Study Group, the Dystonia Study Group, the National Parkinson Foundation, and the American Academy of Neurology.

Stacy has published numerous peer-reviewed manuscripts, book chapters, and review articles on the topics of Parkinson's disease, progressive supranuclear palsy, Tourette's syndrome and other tic and movement disorders. He is also the editor of The Handbook of Dystonia.

For more information on Mark A. Stacy, MD, visit
http://www.dukehealth.org/physicians/mark_a_stacy

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Reply: jerking toe and muscle jerking at night

Dear An_251020, Thank you for your note. It is unlikely that this would be...

Posted by Mark A Stacy, MD

2 Replies | Reply | Watch This DiscussionReport This| Share this:jerking toe and muscle jerking at night Dear An_251020, Thank you for your note. It is unlikely that this would be...

DUKE MEDICINE

Reply: Vision problems

Hi, lovedogs 1955, These accomodation problems are due to stiffness of the muscles...

Posted by Mark A Stacy, MD

32 Replies | Reply | Watch This DiscussionReport This| Share this:Vision problems Hi, lovedogs 1955, These accomodation problems are due to stiffness of the muscles...

DUKE MEDICINE

Reply: Juvenile Parkinson's

Dear Mexican_Baller Thank you for your note. I do not think you have Juvenile...

Posted by Mark A Stacy, MD

1 Reply | Reply | Watch This DiscussionReport This| Share this:Juvenile Parkinson's Dear Mexican_Baller Thank you for your note. I do not think you have Juvenile...

DUKE MEDICINE

Reply: CO-Q10

CoQ10 is an agent being studied to see if it has an effect on slowing the...

Posted by Mark A Stacy, MD

1 Reply | Reply | Watch This DiscussionReport This| Share this:CO-Q10 CoQ10 is an agent being studied to see if it has an effect on slowing the...

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Reply: Over active sex drive with PD

Increased libido is associated with parkinson medications in some patients (~5%)....

Posted by Mark A Stacy, MD

1 Reply | Reply | Watch This DiscussionReport This| Share this:Over active sex drive with PD Increased libido is associated with parkinson medications in some patients (~5%)....

DUKE MEDICINE

Reply: trigger finger

Dear just_another_hill_to_climb Trigger finger often is a term to describe and...

Posted by Mark A Stacy, MD

2 Replies | Reply | Watch This DiscussionReport This| Share this:trigger finger Dear just_another_hill_to_climb Trigger finger often is a term to describe and...

DUKE MEDICINE

Reply: Vision problems

Hi, lovedogs 1955 To me that suggests that you may be right eye dominant, but have...

Posted by Mark A Stacy, MD

32 Replies | Reply | Watch This DiscussionReport This| Share this:Vision problems Hi, lovedogs 1955 To me that suggests that you may be right eye dominant, but have...

DUKE MEDICINE

Reply: parkinsons and rbd

Lee, Thank you for your kind words. Sleep well!

Posted by Mark A Stacy, MD

6 Replies | Reply | Watch This DiscussionReport This| Share this:parkinsons and rbd Lee, Thank you for your kind words. Sleep well!

DUKE MEDICINE

Reply: azilect and tyramine

Dear AN_248640 I apologize for my delay. I thought I had answered this question....

Posted by Mark A Stacy, MD

1 Reply | Reply | Watch This DiscussionReport This| Share this:azilect and tyramine Dear AN_248640 I apologize for my delay. I thought I had answered this question....

DUKE MEDICINE

Reply: parkinsons and rbd

Dear Lee, You are correct that RBD association with PD, is in a older aged cohort...

Posted by Mark A Stacy, MD

Dear Lee,
You are correct that RBD association with PD, is in a older aged cohort - which I think is good for you. I also cannot answer your concern about whether you are at increased risk for PD, but my guess: not likely to increase your risk.

Study of the older group is because that is the population. I searched pubmed to see if there is a better answer. Below is the best I could do.

Sleep Med. 2011 Mar;12(3):278-83. doi: 10.1016/j.sleep.2010.07.022. Epub 2011 Feb 12.
Changing demographics in REM sleep behavior disorder: possible effect of autoimmunity and antidepressants.
Ju YE, Larson-Prior L, Duntley S.
Source
Washington University Multidisciplinary Sleep Medicine Center, USA.
Abstract
BACKGROUND:
Rapid eye movement (REM) sleep behavior disorder (RBD) has been described predominantly in elderly men and in association with neurodegenerative disease. But an increasing proportion of cases in recent reports and in clinical practice do not fit this description; thus we sought to describe a current RBD population and possibly identify new subgroups with RBD.
METHODS:
Records of 115 consecutive patients with polysomnogram-confirmed RBD at an academic sleep center were retrospectively reviewed.
RESULTS:
Male to female ratio was 2:1, and 1.25:1 for early-onset (age <50) cases. Mean age at diagnosis was 53.7±16.4years. Most (60%) cases were idiopathic, and neurodegenerative disease was coincident primarily in older men. Autoimmune disease was unexpectedly common in women (20%) particularly in the 30-49 age groups (40%). Antidepressant use was frequent (46.1%), especially in early-onset cases (57.8%).
CONCLUSIONS:
RBD is diagnosed more equally between men and women and in younger individuals than previously reported. While neurodegenerative disease is frequently co-incident with RBD in older men, most women and early-onset cases have "idiopathic" RBD. High prevalence of autoimmune disease among women with RBD suggests an intriguing link between immune dysfunction and RBD. A high rate of antidepressant use provides support for a potentially causal role for antidepressants in RBD.View Thread

Posted byMark A Stacy, MD

6 Replies | Reply | Watch This DiscussionReport This| Share this:parkinsons and rbd Dear Lee, You are correct that RBD association with PD, is in a older aged cohort...

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