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It sounds like your PD is not as advanced as mine. Residents here are allowed to keep a dog of their own with a doctor's order however I have never been very fond of pets and my limited mobility would make taking care of a dog very difficult. You are absolutely correct about the stress caused by people who don't understand how you can be mobile one minute and immobile just a little while later. I currently find it impossible to walk or stand without having taken two 25/100 carbidopa levodopa along with 200mg of Comtan (the effect of which lasts a little more than 3 hours: the tremors that bothered me at the beginning of my PD have disappeared completely.) Trying to cope with this caused me in my increasing the meds and over time developing the problems involved with long term use of dopaminergic drugs. I am 58 years old and have no children. I moved into the assisted living facility just a year ago and my wife is moving on with her life. I have not been able to make many friends here, but I do see a therapist once a week. I guess there is not much advice anyone can give me. I find myself sitting alone in my room watching television and trying not to think of the impulsive behaviors that vexed me (although reducing the levodopa even more helps.) I can only hope that new research on the subject will set some light on it. Thank you for your reply.
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After this last post I reviewed my previous posts regarding this subject all of which I had forgotten. I attribute my loss of memory to the psychoactive drugs I am taking. Bottom line is that my PD progresses as it inexorably must. Thanks for all your help and kind consideration.View Thread

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You may not be aware of the effects this condition is having on you. You need to do some rersearch on your own and do not discout the need to reduce or eliminate the agonist therapy you are on now.View Thread


You seem to have missed the point of my inquiry entirely. First I have never experienced any hallucinations neither auditory nor visual whatsoever. Secondly my physical symptoms have never included a tremor. The point of the inquiry is; why are my symptoms not progressing taking less 'dopamine replacement therapy', while my tolerance of the drugs had decreased?
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I recently read on the WebMD news site that antipsychotics carry a black box warning for Parkinson's patients. I have been treated for Parkinson's for eight years. Last year because of behavioral problems I was removed from dopamine agonist therapy. As of April of this year I was began taking 1500 mg of Depakote and clozapine 12.5. Since then I have reduced the amount of dopamine replacement therapy (sinemet and comtan) by .25 to .33 of the level that I have been taking for more than two years. After four months I have noticed little change in my Parkinson's symptoms however what is now being referred to in the literature as Parkinson's Psychosis is getting worse again and I want to increase the clozapine by another 12.5 mg.
I was always told that the sinemet would eventually lose its efficacy as the disease progressed, in which case I would have expected to have had to increase the DRT therapy, especially with the elimination of the agonist drug.
At this point in I'm beginning to wonder which came first, the Parkinson's or the psychosis.
So far I have been able to get my blood tested weekly. I am in a supportive living facility and my wife visits once a week. She has been very loving and supportive throughout this whole ordeal.
I am 58 years old, my memory and cognitive abilities are good so I don't think I'm showing any signs of dementia.
If the clozapine is so dangerous should I be considering a skilled nursing facility sooner rather than later. I would value your opinion on this.
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