I WAS IMPLANTED WITH TWO ELECTRODES (BILATERALLY) AND MY PRESENT DOSE OF LEVODOPA IS 3 TO 4 PILLS A DAY (1000 mg.) OF GENERIC SINEMET THAT I TAKE 1/2 ABOUT 2 TO 3 HRS. A DAY, AS I NEED, BUT THE POINT IS THAT IS A BIG TROUBLE TO ME TO FIND THE OPTIMUM DOSE TO FEEL WITHOUT FLUCTUATIONS , BECAUSE THE INTERFERENCE OF MEALS WITH MEDICATION.View Thread
DEAR DR. I'M MIGUIEL FROM MEXICO CITY, Dx, PD SINCE 2002, IN 2010 I WAS IMPLANTED DBS IN GPI, MY NEURO ABOUT 2 MONTHS AGO INCREASED MY PARAMETERS IN MY NEUROSTIMULATOR (BRIO, ST. JUDE) AS FOLLOWING : IMPEDANCE 779, AMPLITUDE (mA)= 4.1, FRECUENCY (Hz)= 150, PULSE WIDTH (mS)= 100, MODE=CONT, ELECTRODES= 9- 10+. I DONT UNDERSTAND VERY WELL THESE NUMBERS AND IÂ´M TAKING NOW ONLY GENERIC SINEMET (250/25 ONLY PRESENTATION AVAILABLE HERE) 1/2 PILL EVERY 2 HOURS AND ALSO I'VE TRIED 1/4 EVERY HOUR BUT I FELT OFF MOST OF THE TIME, PROBLEMS TO WALK AND SPEECH, I MOVE SLOW AND IF I TAKE A LITTLE MORE TO TRY TO IMPROVE THESE RESULT ONLY A FEW MINUTES FEEL GOOD AND THEN I GET OVERDOSE AND GET HORRIBLE DISKINESIA IN MY RIGHT ARM AND LEG BUT NOT AS INVOLUNTARY MOVEMENTS BUT I FEEL A LOT MUSCLE TENSION IN MY ARM AND LEG , SO I CANNOT GET A GOOD FEELING. BUT ALSO, I TRIED TWO CONSECUTIVE DAYS REDUCING MY DOSE TO 1 STALEVO(100 MG) PER DAY, THE FIRST DAY I FEEL VERY MUCH BETTER WITHOUT FLUCTUATIONS BUT MY NEURO TOLD ME NOT TO DO IT BECAUSE I WILL FEEL WORSE AFTER A WHILE AND SECOND DAY I REALLY FELT MORE INCAPABLE TO MOVE, WHAT DO YOU RECOMMEND ME TO DO? ARE THE PARAMETERS CORRECT? I CANNOT FIND A CORRECT DOSE, IT'S FRUSTRATING. PLEASE HELP.View Thread
MY DOCTOR TOLD ME THAT I'M TAKING A LOT OF LEVODOPA 5 OR 6 PILLS A DAY, AND THAT IF I INCREASE MY LEVODOPA INTAKE IT WILL BE A DAY THAT IT DOESN'T MAKE ME ANY EFFECT. IS THAT TRUE?. BUT ALSO, MY QUESTION IS MORE RELATED WITH YOUR OPINION ABOUT MY STIMULATION PARAMETERS, SHOULD BE INCREASED ANY OF THEM? THANK YOU VERY MUCH FOR YOUR ADVICES. GOD BLESS YOU.View Thread
DEAR DR. MARK I'M MIGUEL, I'M 47, I WAS DX.PD SINCE MAY 2002, LAST AUGUST 2010, I HAD MY DBS SURGERY, I WAS IMPLANTED TWO ELECTRODES IN GPI BILATERALLY, I BOUGHT THE BRIO SYSTEM FROM ST.JUDE, PRIOR TO MY SURGERY MY MOST DISTURBING SYMPTHOMS WERE DISKINESIAS MAINLY IN MY LEFT SIDE, RIGIDITY, SPEECH PROBLEMS, ON/OFF FLUCTUATIONS, IMSONIA, BALANCE AND WALK PROBLEMS, (AND DYSTONIAS AT WAKE UP ON FEET IF DON'T TAKE SINEMET) . AFTER SURGERY, I FELT VERY GOOD BECAUSE DISKINESIA GONE, BUT MY OFFS ARE MORE SEVERE.
MY INITIAL NEUROSTIMULATOR PARAMETERS WERE C.1 C.2 , AM.=1.0, RATE=130 Hz. P.W.=100, CONT. 1+ 2-, AND AFTER TWO WEEKS MY NEURO ONLY MODIFIED AM.=1.20
I DON'T UNDERSTAND WHAT THIS PARAMETERS MEAN, AND PRIOR TO MY SURGERY I WAS TAKEN 1 SINEMET PILL EVERY 3 HOURS, 2 PRAMIPEXOLE(SIFROL 1 mg) A DAY, AND 1 CLONAZEPAM AT NIGHT TO SLEEP. MY DR. ONLY HAS INCREASED AM=1.40, BECAUSE HE SAID HE WANTS THE BATTERY EXTEND TO MAX. USEFUL LIFE, AND TOLD ME I MUST REDUCE LEVODOPA INTAKE, AND TOLD ME TO TRY NOW, WITH ROTIGONE PATCH 1/DAY, AZILECT 1/DAY AND STALEVO INSTEAD OF SINEMET BUT I TRIED STALEVO 50 AND OCCURS THAT MY OFFS ARE MORE SEVERE AND TRIED ALSO WITH STALEVO 100 MY ON TIMES MAKES ME FEEL BETTER A SHORT TIME AND THEN WHEN THE EFFECT RAISE TO PEAK I CANT TALK. I COME BACK TO SINEMET BUT ARE THE EFFECTS ARE LESS BUT SIMILAR MY SPEECH IS VERY SENSITIVE TO SINEMET DOSES. LESS SINEMET=OFF SEVERE, REGULAR SINEMET= I HAVE TO WAIT TOO MUCH TIME TO TAKE EFFECT TO BE OK, MORE SINEMET= I CAN'T TALK, I HAVE 3 WEEKS USING THE PATCHES AND AZILECT AND I DONT FEEL ANY EFFECT OF THESE 2 MEDS. WHAT I SHOULD DO? I WILL APPRECIATE VERY MUCH YOUR COMMENTSView Thread
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