My 85 yr old Mom diagnosed about 4 or 5 yrs ago finally started treatment 2 yrs ago. Took Senemet without problems for a year, then about a year ago doc increased her Sinemet dosage to 1.5 tablet 3 times/day and she began having severe abdominal cramping episodes--not interal cramps but more (she says) like someone is pressing down on her abdomen very hard with great pressure. Puts her in misery. Switched to Requip XL (long transition) which seemed to resolve the cramping but her gait deteriorated seriously and she began to experience drooling even with the addition of 1/2 Sinemet 3X day. Back to Sinemet at previous levels--cramping returned--now trying 1/2 Sinemet up to 6 time/day to see if that works. Also taking as of recently, Carbidopa/levodopa CR at bed. She is a 90-pound woman and al of these medication changes are very hard on her (and me). Has anyone else had this experience with Sinemet?View Thread