This is a bit off-topic for a board on pet health issues. But to answer your question (who doesn't like to talk about their own kitty!) ... my cat, "Lisabelle" is a pedigree RagaMuffin. She was actually a gift to me from one of the founding breeders. Lisabelle is a "blue-cream and white", i.e. a dilute tortie and white.
The RagaMuffin breed was first registered as a breed in 1994 in the American Cat Fanciers Association (ACFA) and received full breed "championship" status in ACFA in 2001. The breed was first registered in the Cat Fanciers Association (CFA) in 2003 and received full championship status in CFA in 2011.
The breed shares some common origins with the Ragdoll ... i.e. the cats bred by Ann Baker in California in the 1960s. But it is a separate breed and developed differently with a larger gene pool ... which allows for a wide range of colors and patterns. Similar to the Ragdoll, "Muffins" are very people oriented and have a tendency to "flop", i.e. go limp when picked up (not true of all RagaMuffins, but of many). The coat is what I love the most. Lisabelle's coat is medium in length and extremely dense (it is hard to find skin), yet never mats ... and is the softest thing I've ever touched, like rabbit fur. Again, not every Muffin has the perfect RagaMuffin coat ... but Lisabelle does, and I love it.
The breed club started by the founders is: RagaMuffin Associated Group (RAG). Our website is in the process of being redone but you can google the old one. We also have an active Facebook page. You can learn more about the breed from some of our breeder websites.
That said ... I also care for 3 "unowned" apartment complex cats (one of which is currently at NC State vet school having the radioactive iodine treatment done to cure her hyperthyroidism). Those three chose me and are also wonderful, loving cats. So, I highly recommend RagaMuffins and know many of the breeders ... but you can also find wonderful cats in shelters as well.
However, the recommendation for pre-testing is not because the vaccine will cause a false positive. Rather the reason is that if a cat does have FeLV, then the vaccine is of no benefit. Giving it won't hurt, but if already infected, the vaccine will not help.
As for the vaccine causing future tests to be falsely positive ... that does not appear to be the case. I'm not a vet, but one of the co-authors of the AAFP Vaccination Guidelines, Dr Richard Ford (emeritus at NC State), is a friend and mentor. I've spoken to him often about this. He actually did some studies with FeLV vaccines to see if they would cause a false positive on FeLV tests. His studies showed that they do not cause false positives. The Retrovirus Guidelines do say that there "might" be some false positives for a week or two after vaccination ... but there doesn't appear to be any published study to support that. I think it is more of a cautionary statement.
Here are a few comments about FeLV vaccines and tests that you or others may not know.
1. There are two types of FeLV vaccines on the market. As you mentioned, all are Killed Virus (aka "inactivated") ... EXCEPT for one FeLV vaccine which is recombinant. That is a very important distinction and many/most recommend using the recombinant vaccine when possible. Recombinant vaccines are made by using a live carrier virus (called a "vector") ... then taking just a small piece of FeLV DNA (not the whole virus) and inserting it into the vector virus. The only available recombinant FeLV vaccine (Merial's Purevax rRabies) uses the canarypox virus as a vector. It is unique because it is a bird virus that cannot replicate inside a mammal. So, the live recombinant canarypox is injected into the cat. But when it tries to reproduce, it breaks apart and delivers the small piece of FeLV DNA that stimulates the production of protective antibodies to FeLV. Recombinant vaccines do not contain the entire virus ... so, it is impossible for a cat to get FeLV from the vaccine. One big advantage of recombinant vaccines over killed is that recombinant vaccines do not contain any adjuvant ... which the killed vaccines need in order to get the immune system to respond to a dead virus. Adjuvants work by creating chronic inflammation at the vaccination site ... and it is known that chronic vaccination can lead to a deadly cancer (fibrosarcoma) in a small number of cats. There is a well known history of cats developing cancer at the vaccination site after a killed-virus FeLV vaccine. While some claim it is a small number ... when it is your cat, the percentage is unimportant.
2. All of the tests for FeLV look for antigen (part of the actual virus) and NOT for antibodies. So, while cats will develop FeLV antibodies after vaccination, they will not cause a false positive with any FeLV test. That is in contrast to the other common retrovirus, FIV. Tests for FIV do look for antibodies, and cats that have been vaccinated for FIV will test positive, whether or not they have the virus. It is unknown how long the FIV antibodies will remain, but it is thought to be at least several years. That is one reason (among others) that the FIV vaccine is not often given and generally not recommended by most.
3. There is an in-clinic FeLV SNAP test that most vets use as an initial test, and only send to a lab when they have a reason to doubt the results.
Sorry to be so long winded ... just trying to be helpful.
Let me add another reason that many would advocate a canned food diet:
4. Canned food can be helpful when having to give certain medications or supplements to cats. That tends to become more of an issue as cats age and have health issues. It is easier to mix some things into food ... like the amino-acid, L-lysine, if a cat has herpesvirus, a common cause of upper respiratory problems ... or probiotics, which might be something you want to give if your cats have some intestinal issues, etc. I've heard many people lament that they couldn't give a pill to their cat ... and since the cat would only eat dry food, they couldn't put the pill in food or something like a pill pocket.
For all of those reasons, I (and most of the experts) think it is best to give either a canned food only diet, or at least some canned food on a regular basis. The brand is not that important, though I always look for something that is high in protein and with as little fruits/vegetable as possible. I avoid the "chunks and gravy" type canned food because the gravy is high in carbs. Actually, even some of the veterinary nutritionists agree that one of the better canned foods are the Fancy Feast "pates" ("Classic" type). I feed that to the outdoor community cats that I take care of. A friend of mine who is a top veterinary internal medicine specialist actually feeds his cat Friskies canned food and she does great on it. So you don't have to get an expensive designer food.
If you are looking for another dry food ... I know of a number of people who really like one called "Young Again". I'm not sure it is available in stores but you can get it online: https://www.youngagainpetfood.com/ It even claims to have a "zero carb" dry food ... though I still don't know how that is possible. But many feel their cats do very well on it. Personally, if your cats like canned food, I'd keep giving it. If your cats have some intestinal issues, giving probiotics in the food may be helpful. It isn't a treatment for current problems but helps to build up the good bacteria in the gut which can help prevent future problems. It is more of a long-term help.
Sorry for the long reply but wanted to help since the vets here seem to have disappeared.
I'm not a veterinary nutritionist, so can't give an authoritative reply. But one thing I've learned after years of hearing people talk about what they think is the best and worst foods for cats ... is that every cat is different. For nearly every brand of food, some cats will do very well on it, and others may get sick or just not do well on it. Given that you had more than one cat vomit after eating Proplan, it only seems logical to try switching to another food. Even if other cats do well on Proplan, your cats do not seem to ... assuming it is the reason for the vomiting and/or pancreatitis, etc.
That said ... if your cat is eating canned food now ... that's GREAT! My "hobby" is listening to talks given at veterinary continuing education conferences by some of the top veterinary specialists and researchers. There are varying opinions among them, but the majority would encourage feeding a canned food diet (and even better, with added water) ... over a dry food. There are several reasons for that:
1. Dry food, obviously, has very little water in it. Cats began as desert animals and as a result have a very low thirst drive. Cats that eat dry food will drink more water, but it is felt that they do not (and can not) drink enough to make up for the lack of water in their food. Many cats do well on dry food because they can concentrate their urine well when young and healthy. However, as they age and become prone to kidney disease, the lack of water ... and likely chronic sub-clinical dehydration ... can increase the progression of kidney disease. Also, hydration is very important for pancreatitis and a dry food diet may contribute to bouts of pancreatitis. The concensus among most experts is that we need to get as much water into our cats as possible ... and feeding a canned food diet (with added water) is one good way to do that. For cats with any type of kidney or urinary issue, the first thing a vet will do is to recommend a canned food diet, for the added water. Why wait until a cat develops kidney disease?
2. Dry food, by its nature, is high in carbohydrates because it generally requires carbs to make the pieces of kibble retain their shape. More and more of the feline specialists and nutritional experts (like Dr Susan Little and Dr Debra Zoran, among others) are advocating a high protein, moderate fat and LOW carbohydrate diet for cats. Cats are obligate carnivores which means that they need an animal diet (meat, internal organs, bone, etc) to get their needed nutrition. They can process some carbs and vegetables ... but not as efficiently and they cannot get all the necessary nutrition (like taurine). Their natural diet of small prey is high in animal protein and very low in carbs. But dry food usually is quite high in carbs and low in protein. Canned food, no matter the brand, usually has higher protein content and lower carbs than dry food. Whatever food you feed, it is best to look for something that is higher in protein.
3. Feeding canned food can better control a cat's weight. Obesity is often a problem with cats fed a dry food diet that they can graze on throughout the day. Dry food is VERY calorie dense (because of the lack of water) and cats can easily eat more calories than needed. Canned food has water that helps fill the cat up and eat less calories. Also, protein helps make a cat feel full ... and since canned food has higher protein, a cat will feel full sooner and less likely to over eat. Also canned food is usually fed in "meals" and not left out to graze on during the day ... again reducing calorie intake.
I'm running into the letter limit for this reply ... so let me continue my response in another reply ....
Sorry for the long reply, but I suspect you want this info. So, continuing my reply above ....
The giving of lysine for herpes is falling out of favor with some experts now because of a few studies that have shown that it didn't help cats with an active infection. But it appears to be quite safe to give long-term to cats and may help some. As mentioned above, some, like Dr Ford, feel that lysine may help keep herpes in a latent (dormant) state, thus reducing or eliminating future flare-ups.
The good news for herpes is that there IS an antiviral medication that is safe to use in cats and has become the "go-to" medication to treat active herpesvirus-1 for most experts. It is called famciclovir (brand name is Famvir). Nothing will cure herpes, but famciclovir helps many cats to get it under control and stop the sinusitis. For cats with ocular signs (e.g. conjunctivitis and eye ulcers), another antiviral, cidofovir, can be reformulated by a veterinary ophthalmologist to use as a topical eye drop.
So, I'd encourage you to ask your vet about trying Famvir. I think it is okay to use in a 4-month old kitten, but that is something to ask your vet about. Famvir will not help if the virus is calici, but it seems to be worth trying since it may be herpes.
Another thing to be aware of is that it is common to have a secondary bacterial infection. It is made worse because the structure of the nose contains many microscopic bones, called the turbinates that help filter the air ... and herpesvirus can permanently damage the turbinate bones in the nose. The result is that it produces an environment that promotes bacterial growth. Nothing can be done to correct the damage to the turbinates ... and it makes cats susceptible to bacterial infections for life. Antibiotics can help while they are being taken ... but once stopped, the bacteria repopulate. As mentioned above, using an intranasal vaccine once or twice a year may help some cats. The intranasal vaccine stimulates a local antibody response in the mucous membranes in the nose which can help control the signs of sinusitis. Hopefully, your kitten won't have that problem, but if you have ongoing problems, that may be the cause.
One final note. You mentioned that your kitten was up-to-date on vaccines. Was the final kitten series dose given at 16 weeks or later? That is very important, particularly for the panleukopenia portion of the vaccine. Studies have shown that when the last kitten vaccine is given at 12 weeks, about a third do not develop antibodies to panleukopenia (which can be fatal). The reason is that there is interference from the maternal antibodies that the kitten receives from its mother when nursing during the first 24 hours after birth. There can be interference with vaccines until 15 weeks or so. Thus it is recommended to give the final vaccination at or after 16 weeks. Also, a modified live vaccine should be used ... not a killed virus ("inactivated") vaccine. Modified live gives better protection with a quicker onset of immunity.
Even when up-to-date on vaccinations for herpes and calici ... cats can still become infected. No vaccine for herpes/calici will prevent infection, nor prevent shedding of the viruses (which could infect other cats). The vaccines are said to give "non-sterile" immunity which means that they don't prevent infection but will lessen the severity of symptoms once infected. Since herpes and calici can be fatal in some kittens, the vaccines are very important to give. Just wanted you to know, if your kitten has herpes or calici ... it is not a failure of the vaccine.
I'm not a vet, but I am friends with and mentored by one of the top veterinary infectious disease experts in N America, Dr Richard Ford, now emeritus at NC State. He continues to be full-time on the veterinary continuing education circuit where he regularly lectures on feline upper respiratory diseases. He is also one of the top experts on vaccines and vaccination protocols, and a co-author of all versions of the AAFP Feline Vaccination Guidelines. I can't speak for Dr Ford, but I can share some of what I have learned from him. I've attended his talks numerous times and had many hours of conversation with him. Hopefully, I've learned something.
Up until your final sentence, it sounds like an upper-respiratory infection (URI). Your last sentence suggests that there may be some lung involvement if she is having difficulty breathing. If your vet hasn't done so already, an x-ray would be helpful to check out the lungs, if she also hears lung sounds on exam.
That said, I'll share some info on URIs which seems to be a component, if not the primary issue.
It is felt by the experts that the vast majority (ca 80% or so) of URIs in cats have a virus as the primary problem ... and then may have secondary bacterial infections. The two viruses that are extremely common in cats are feline herpesvirus-1 (FHV-1) and feline calicivirus (FCV). Both can cause sneezing and sinusitis. Herpes tends to be involved when there are also ocular signs (watery eyes, and in more severe cases, ulcers on the eye) ... while calici is more often associated with oral ulcers. But Dr Ford has said that it can be difficult, even for the experts, to tell if herpes or calici is the cause, based on URI signs.
Antibiotics will not work against any virus ... antibiotics only treat bacterial infections. That can account for the lack of resolution with the antibiotics. But since there may be a secondary bacterial component, antibiotics may help to control that part of the problem.
Unfortunately, if the problem is calicivirus, there is no medication to treat it. There are drugs that will kill calici, but they also kill the cat ... a bit counterproductive. With calici, one can just give supportive care (e.g. flushing the sinuses to clear out some of the gunk). The good news is that most cats will clear the calicivirus on their own after a few weeks. A small number are calici carriers and may have long-term problems. One "treatment" that works for some cats is actually just giving them an intranasal vaccination (i.e. either the Heska or Zoetis/Pfizer 2-way intranasal vaccine for herpes/calici). Here is a link to a Q&A on Dr Ford's website where he addresses this. The website has gotten out-of-date but this info is still current. http://dvmvac.com/QAvacBB.shtml#fcore
With herpesvirus, nothing will cure it and nearly all cats infected have it for life ... BUT a good immune system can put it into an inactive "latent" state in which there are no signs of disease. It is common for stress to reactivate (recrudesce) herpes ... which is why kittens often have flare-ups soon after they are rehomed, which is a stressful event. The good news is that there are some treatments for it that won't cure it but can help to get (and keep) it in its latent state (no symptoms).
The fact that your vet gave you Viralys suggests he/she feels the problem is herpes. Viralys is a form of the amino acid L-lysine. Lysine helps by slowing the replication of herpes. In a mild case, it can be enough to give the immune system a chance to get herpes under control. But in severe cases, it doesn't usually help a lot. Dr Ford feels that lysine is better at keeping herpes in a latent state, than it is in treating an active flare-up. Many cats with chronic sinusitis from herpes are given lysine for life (it can also be given as a powder mixed into canned food).
Ooops, running out of space, will continue in next reply.View Thread
I'm not sure where milessmith is getting his information. I can say that the veterinary experts who wrote the 2011 AAHA Canine Vaccination Guidelines (which is used as the standard in N American veterinary medicine) would NOT recommend a Bordetella bronchiseptica vaccine be given ROUTINELY to dogs every six months.
One of the co-authors of those Guidelines, who lectures at vet CE conferences regularly on vaccination protocols, Dr Richard Ford (emeritus at NC State vet school), is a friend and mentor to me. I have listened to many of his talks, read many of his published articles and talk to him often about vaccinations. I can't speak for him, but he feels I have a good understanding of the issues.
1. Bordetella bronchiseptica (Bb) is a NON-Core vaccine ... which means that it is only recommended if a dog has a known high risk of exposure, e.g. about to be boarded at a kennel, regular time in a dog park, dog shows, etc. It is not recommended automatically for all dogs.
2. There are three different types of Bb vaccines ... with three different routes of administration: injectable, intranasal, oral. The immune response and booster intervals differ based on the vaccine used. However, in all cases, studies have shown that the duration of immunity (DOI) is at least a year. Of course, not all dogs respond to vaccines in the same way and there are no guarantees. The AAHA Guidelines recommend boostering "annually or more often in high risk animals".
It is critical that Bb vaccines be given ONLY by the route of administration that the vaccine is labeled for, ie, NEVER inject an intranasal or oral Bb vaccine (can result in death) or give the injectable Bb in the nose or mouth (will not give protection).
a) Injectable ("parenteral") - The only injectable Bb vaccine is a killed ("inactivated") vaccine. Immunologically, the initial vaccination (i.e. first time the dog has been vaccinated for Bb, regardless of age) requires a SERIES of TWO initial doses, given 2-4 weeks apart ... plus a week to respond, before there is immunity. A dead (killed/inactivated) bacterial vaccine is not very immunogenic and is generally not recommended EXCEPT for dogs that are very aggressive when giving the intranasal (or oral) vaccine. Giving a shot is preferred to having a vet lose a hand trying to put vaccine in the nose.
b) Intranasal (IN) - This is a modified live ("avirulant") vaccine that is preferred by most of the experts. It can be given at a younger age (as early as 3-4 weeks) and requires only a single initial dose which can give immunity as quickly as 72 hours. IN vaccines give a better local (in the nose) immune response which is beneficial for an upper-respiratory infection. Also, most IN Bb vaccines come in combination with at least Parainfluenza vaccine ... which is another cause of "kennel cough". Giving both Bb and Parainfluenza as an IN vaccine is felt by most to be the best way to give protection to at-risk dogs.
c) Oral - The oral Bb vaccine came out after the 2011 Guidelines were published. It is also an avirulant live vaccine and shares characteristics with the IN vaccine (but is different, and formulated to work through absorption by the mucous membranes in the mouth/cheek). Last I heard, the duration of immunity was not known, but annual boosters are recommended.
Remember also ... there is no single thing that is "Kennel Cough". The experts now prefer the term "CIRD" (Canine Infectious Respiratory Disease) which can be caused by a variety of viruses and bacteria ... most of which do not have a preventative vaccine available.
Bb is non-core and vaccination is recommended only when there is a high risk of exposure. Even then, generally boosters are recommended annually, unless, perhaps, a dog is entering a shelter or kennel with an active Bb outbreak, then more frequent boosters may be recommended.
The key to FIC seems to be STRESS. Dr Buffington and Dr Chew (and others) have shown a direct connection, though the exact mechanism is still unknown. Dr Chew likes to emphasize that they believe that FIC is more of a neurological disease (how the brain responds to stress) than simply a bladder problem. For that reason, Dr Buffington coined the term "Pandora Syndrome". It is felt that it may be a factor in other chronic problems common in cats, but for most, the bladder effect is the first noticed ... i.e. when cats pee outside the litterbox or make multiple trips and have bloody urine.
What is known is that cats prone to FIC have a physically different reaction to stress. In normal cats, stress begins a series of hormonal responses that activates the "sympathetic nervous system" (SNS) ... which is what causes the "fight or flight" response. For normal cats, once this is activated, it is also quickly turned off. That results in the sudden burst of energy that we all experience when scared or startled and then a return to normal.
But for FIC cats ... there is a problem and the SNS does not get shut off properly. The SNS releases a hormone called norepiniphrine. In FIC cats, there is a continued presence of norepinephrine throughout the body. It has an effect on the cells that line the inside of the bladder and normally cause a mucosal layer that protects the bladder wall from the noxious urine. The norepinephrine causes changes to those protective cells and they become more porous and allow urine to contact the inner bladder wall ... resulting in inflammation, and also increasing and activating nerves and pain receptors ... hence the pain of cystitis.
While the exact mechanism is unknown, it is interesting that research has shown that cats that are prone to FIC have smaller than normal adrenal glands. While the glands are structurally okay, it seems to cause some adrenal insufficiency that may be a factor in FIC. Dr Buffington has a theory (not yet proven) that pregnant cats that become stressed at the point when the adrenal gland is forming in the fetuses, may be the cause of the smaller adrenal glands and the kitten's tendency towards FIC.
What Dr Buffington and Dr Chew have discovered is that by controlling the stress, the frequency of FIC episodes diminishes or disappears. The trick is identifying the source of stress and correcting it. That is what they try to do with the IndoorPetInitiative website.
One area of stress that is sometimes overlooked is the stress of the OWNER. Cats easily pick up on stress of their humans and become stressed. It has been observed at vet schools that just before exams, there is an influx of cats with FIC that belong to the vet students. Dr Chew comments that for every holiday for which Hallmark has a card, there are increased cases of FIC (because of stressed out humans). Moral ... take care of yourself, too!
Most episodes of FIC will resolve on their own in 5-7 days without any other treatment (if the stress can be controlled). So, some think that antibiotics help when in reality the FIC would have resolved without them. Most would recommend giving a cat with active FIC some pain medication (buprenorphine, brand name: Buprenex is commonly used).
Increasing the water intake is always beneficial in order to keep the bladder flushed out and dilute the urine to make it less noxious. It also reduces the chance of plugs or stones forming because the urine doesn't sit in the bladder so long. Thus, if your cat will eat it, any canned food with added water is better than a dry diet.
Guess that is enough for now. I hope I've helped a little. Sounds like stress is a factor for your cat with the new cat. If that relationship can improve, the FIC may also improve.
What you are describing (multiple trips to the litterbox, peeing blood, etc) sounds like classic FIC (Feline Idiopathic Cystitis) which is now being called by some experts "Pandora Syndrome". FIC is NOT a bacterial infection (hence antibiotics will not treat it). Rather FIC is an INFLAMMATION of the bladder which can be extremely painful to the cat (and human women, many of whom are also prone to idiopathic cystitis).
The end of that article directs one to another important site for you to look at ... but they use an outdated link. What began as the "Indoor Cat Initiative" on the Ohio State Univ vet school website ... was later renamed the "Indoor Pet Initiative" because dog people wanted to be included. But the site is done by Dr Tony Buffington (one of the foremost experts on FIC) at Ohio State and he intended it primarily to deal with cats with FIC and stress issues. Here is the current link: http://indoorpet.osu.edu/
I'm just a pet owner, but my "hobby" has been listening to, and attending when possible, talks given at veterinary continuing education conferences by some of the top veterinary experts and researchers. Over the past few months, I've gotten to know Dr Dennis Chew, one of the top veterinary urologists/nephrologists in N America who is now emeritus at Ohio State but is nearly full-time on the vet CE circuit, lecturing to vets. Just over a month ago, I was given permission to attend the NC Veterinary Conference in Raleigh ... and attended 8 talks by Dr Chew (including 2 on FIC/Pandora Syndrome). He is becoming a friend. Dr Chew has worked with Dr Tony Buffington, and FIC has been one of his areas of interest and research.
Last summer I wrote an article on FIC for a Persian magazine based on one of Dr Chew's talks and he reviewed it for me (which led to him inviting me to attend his talks in Raleigh). I can send you a copy if you give me your email address (you can send it to me at: motherstephania at gmail dot com).
Okay, a little info on it here.
If this is an ongoing problem, your vet will want to first rule out other causes. True bacterial urinary infections (UTIs) are VERY UNcommon (1-3%) in cats that are under 10 yrs old. True UTIs tend to be more common in older cats that have more dilute urine (often as a result of kidney disease, diabetes, hyperthyroidism, etc). But to rule out the possibility, a urine sample has to be taken by cystocentesis (needle directly into the bladder) so that the urine is not contaminated by bacteria on the way out or on the fur with a voided sample. You're right, it generally takes a few days to see if anything grows on a culture. You also would need to stop antibiotics for a few days/week before getting a urine sample to test for bacteria.
Your vet will also want to rule out something like bladder stones. Most (but not all types) can be seen on an x-ray. If stones or other things (tumor, blood clot) are suspected, or to rule out other types of stones, then an ultrasound might be done. On the other hand ... urinary CRYSTALS are nearly a non-issue, even if they were present. Dr Chew states strongly that they are not a factor in causing FIC. The only time they become important is for males who may be prone to forming a urinary "plug" that would block the urethra so they can't pee ... which can become fatal in males. Blockages are extremely rare in females because they have a wider urethra ... so, is not likely an issue for you. Dr Chew encourages vets to forget about crystals.
I'm running out of my allotted reply space ... so, I'll continue this in another reply. Sorry I am so wordy, but I suspect that you want this info.
For the core vaccine, DA2PP (Distemper, Adenovirus-2, Parvovirus and Parainfluenza) ... the booster recommendations on the manufacturer's label reflects the testing interval used when they licensed the vaccine with the USDA CVB (Center for Veterinary Biologics). It is ONLY a recommendation and not a requirement.
One of the co-authors of the AAHA Canine Vaccination Guidelines, Dr Richard Ford (infectious disease and vaccinology expert, emeritus now at NC State vet school) is a mentor and friend of mine. I've heard many talks by him and others given at veterinary continuing education conferences. So, I can try to relay some of the info I have learned.
All of the DA2PP vaccines are modified live virus vaccines and give good protection. After the initial puppy series (that should be given until the puppy is at least 16-18 weeks of age) ... then the first booster should be given one year later (i.e. when the dog is about 1 yr and 4 months old). Even if the initial vaccination is given to an adult dog, they usually recommend the first booster be given after one year.
Thereafter, the 2011 AAHA Guidelines recommend boosters for DA2PP "no more often" than every 3 years. In reality, most dogs are probably protected for life for DA2P (distemper, adenovirus-2 and parvovirus). But there are some dogs that do not respond as well to vaccines, so they still generally recommend boosters every 3 yrs or so. Any modified live DA2P vaccine can be used ... whether labeled for 1 or more years.
Booster decisions should be made based on the individual dog's lifestyle and risk of exposure. If the dog is frequently exposed to other dogs with unknown vaccination status, etc (e.g. dog parks, shows, etc) then you and your vet may decide to vaccinate every 3 years or more frequently. Most pet dogs probably don't need boosters for DA2P more often than every 5-7 years (if ever), if they have a low risk lifestyle.
Be aware, though, that some individual dogs can be "non-responders" ... i.e. do not respond to vaccines, no matter how many they receive. And no vaccine will protect 100% of dogs, 100% of the time. So, giving periodic boosters is certainly fine to do. If your dog has a fairly low risk of exposure and is otherwise healthy, then he shouldn't need annual boosters for DA2P.
You can always do a titer test a couple weeks after vaccination to see if there is a response to the vaccine. If so, the dog is probably protected for many years for those core diseases. On the other hand, older dogs with previous vaccinations may not have a titer, yet still be protected ... because vaccines "teach" memory cells that will respond quickly to produce more antibodies if it sees the disease in the future.
For the DA2PP vaccine ... veterinarians do not have to follow the "1-yr" booster recommendation.
HOWEVER ... for the RABIES vaccines ... veterinarians, legally, MUST follow the booster interval for the vaccine given ... i.e. labeled for 1-yr or 3-yrs.
Also, for the non-core vaccines (only given if there is a significant risk of exposure) ... nearly all require ANNUAL boosters. That's because the vaccines are either "killed" (inactivated) which do not give good protection ... or, they are vaccines for bacterial agents which don't work as well as the viral vaccines. So, non-core vaccines such as lyme disease, leptospirosa and canine influenza ... all require annual boosters ... IF they are given at all.
I don't know that the annual vaccinations are responsible for your dog's skin issues, that may just be coincidental. But the experts do try to limit the vaccines for small breed dogs (adult weight of 20lbs or less) ... particularly multiple vaccines given at the same time.
If your dog has had the DA2PP vaccine annually for 3 years, and doesn't have an abnormal risk of exposure, he probably doesn't need a booster for at least 3 years (or more).