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Metformin decreases the level of androgens produced by the ovaries and adrenal glands. It also helps the body use insulin and may reduce the risk of diabetes .
Metformin lowers blood sugar levels by:
- Decreasing the amount of sugar produced by the liver .
- Increasing the amount of sugar absorbed by muscle cells and decreasing the body's resistance to insulin (insulin resistance ). When blood sugar is lower, less insulin is needed, so the body makes less insulin. And when insulin is lower, the body produces a lower level of androgens. Metformin is a diabetes medicine sometimes used for lowering insulin and blood sugar levels in women with polycystic ovary syndrome (PCOS) . This helps regulate menstrual cycles, start ovulation , and lower the risk of miscarriage in women with PCOS. Long-term use also lowers diabetes and heart disease risk related to high insulin levels.1 Metformin may be useful in restoring regular menstrual cycles and starting ovulation in about 45% of women with PCOS





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