I have also been taking levothyroxin since college, and was just recently diagnosed w/PCOS. I take Metformin twice a day and just try to take the thyroid meds separately - first thing in the morning. Then I wait as long as possible before having breakfast, and take the metformin after I eat, and at dinner as well. I've only been on the combination for about 4 weeks now, have also tried to limit sugars, and have worked out a LOT. So far it seems to be helping! I've lost about 10 lbs and my acne has cleared up some. Got my period earlier than typical too. (Normally 8-10 weeks apart) My Dr. said the key is to use the meds in conjunction w/exercise and diet. Stay away from sugar and bad carbs!View Thread