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in Jan 2008. Initial PSA was 4.47 (while on oral finasteride). Pathology revealed positive margin at the bladder neck and minimal microscopic
involvement of one seminal vesicle. Gleason score was 7 (4+3).
One year later PSA increased and I underwent radiation therapy.
In spite of this, PSA rose 10 months later. Doubling time of PSA appeared to be about 3 mo. 0.38, 0.78, 1.44. Combined androgen blockade was started. First PSA was 0.14 and all subsequent tests
are below level of detection (?< 0.10). I am now at 15 months on CAB
and am trying to decide the value/risks of attempting intermittent therapy with CAB. I feel fortunate to have experienced this response.
I am aware of potential benefits but have trouble assessing whether
there is a risk of earlier androgen independence. I would be interested
in hearing professional opinion on this matter. I am aware that there are not prospective studies available to help answer this question..View Thread



post laparoscopic prostatectomy and subsequent radiation therapy
for early recurrence of a tumor with rapid doubling time. PSA fell quickly and remained less than 0.1 for 15 months. I have now chosen to go on intermittent therapy: however testosterone levels have not risen after the long period of supression. Since we are trying to get the levels to increase in order to diminish side effects, would one consider use of testosterone patches with close PSA monitoring should levels not increase.View Thread

Thanks for your input. Intermittent therapy allows the testosterone to increase naturally as the blockade is removed.
Since the time to increase is variable and may be delayed, it does not seem unreasonable to provide external testo if it does not increase. As with all interventions, the testo and PSA levels would be monitored and blockade would be reinitiated at a predetermined level. kgView Thread

in Jan 2008. Initial PSA was 4.47 (while on oral finesteride). Pathology revealed positive margin at the bladder neck and minimal microscopic
involvement of one seminal vessicle. Gleason score was 7 (4+3).
One year later PSA increased and I underwent radiation therapy.
In spite of this, PSA rose 10 months later. Doubling time of PSA appeared to be about 3 mo. 0.38, 0.78, 1.44. Combined androgen blockade was started. First PSA was 0.14 and all subsequent tests
are below level of detection (?< 0.10). I am now at 15 months on CAB
and am trying to decide the value/risks of attempting intermittent therapy with CAB. I feel fortunate to have experienced this response.
I am aware of potential benefits but have trouble assessing whether
there is a risk of earlier androgen independence. I would be interested
in hearing professional opinion on this matter. I am aware that there are not prospective studies available to help answer this question..View Thread

in which the mentioned muscle is inflamed and in spasm.
I would recommend that you read about rectal pain and
this syndrome and see which of the various descriptions
best fit with your symptoms. I would then try some of the
recommended therapies. The fact that you have had it for many years makes it unlikely that there is a serious cause.View Thread

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