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After eight years, the researchers found that the risk of death from prostate cancer among statin users was one per cent compared with five per cent for non-users.View Thread
What are some symptoms of prostate cancer?
In its early stages, prostate cancer usually doesn't produce any noticeable symptoms. Unfortunately this is the reason it sometimes can spread beyond the prostate gland. Many times, prostate cancer is found during a routine screening.
Many of the earliest symptoms of prostate cancer affect the bladder, because the prostate tumor usually puts pressure on the bladder or the urethra, the tube that carries the urine. However, many bladder problems in men are also caused by benign prostate problems such as infections or an enlarged prostate (benign prostatic hyperplasia). When urinary symptoms occur, they can include:
- Blood in urine, or semen
- Decreased force of the urine stream
- Starting and stopping while urinating
- Trouble urinating
- Pain/discomfort in the pelvic region
- Leg swelling
- Bone fractures
- Constant pain in the bones
- Spine compression
Who is at risk for developing prostate cancer?
Men who are 50 years old and older have an increased chance of developing prostate cancer. Also, without known reasons, it has been found that black men have a higher risk of developing and dying from prostate cancer than other races. If a man's father or brother has developed prostate cancer, his risks are much greater to also develop the disease. Some studies have also shown that a high-fat diet and men who are obese have an increased risk of developing prostate cancer. One theory has been studied that fat increases the production of the testosterone hormone, which may increase the development of prostate cancer cells.
What are some ways to prevent developing prostate cancer?
A healthy diet: Limiting intake of high-fat foods and increasing daily intake of healthy foods like, fruit, vegetables and whole grains will help reduce the risk of developing prostate cancer. Eating certain foods that are rich with the antioxidant, lycopene such as, tomatoes or tomato products, watermelon, grapefruits, garlic, arugula, bok choy, brussel sprouts, broccoli, cauliflower and cabbage also aid in reducing the risks.
Exercising regularly:
Having a regular, consistent exercise routine will help prevent obesity, and also the possible development of prostate cancer. Exercising on a regular basis will also help prevent high blood pressure, high cholesterol and a heart attack. Although exercising doesn't have a direct connection with the prevention of cancer, it has been proven to strengthen the immune system, speed up digestion and improve circulation- all which play a role in cancer prevention. Regular exercise may also help to decrease the risk of prostate gland enlargement and urinary problems, or benign prostatic hyperplasia (BPH).
Taking Nonsteroidal anti-inflammatory drugs (NSAIDs): These drugs include: ibuprofen (Motrin, Advil, etc.) and naproxen (Aleve). NSAIDs inhibit the enzyme, COX-2 which is found in prostate cancer cells. Although more studies are needed to confirm whether these drugs directly result in lowering the rates of prostate cancer or reduced deaths from the disease, it is possible they might prevent prostate cancer.
Urologist, Urology Surgeons: Doylestown, PA - specializing in urology and enlarged prostate treatment. Cburology.comView Thread
We saw the urologist, who is only in town for a week every month, as we live in a very rural area.
We were told to come back this week, (July 8th) for a prostate biopsy.
I called the office on tuesday, and never got a answer ....or a date
Tomorrow is thursday...........what can I say to the front office staff
to get this biopsy done ???
If I just let it go......... it is another month till the Dr returns.
The Dr is wonderful............the front office staff is NOT.View Thread
What's a man supposed to do? To provide clarity amid the controversy, here's WebMD's FAQ.View Thread
Done by researchers at UCLA's Jonsson Comprehensive Cancer Center, the short-term study also found that the men on the low-fat, fish oil supplement diet were able to change the composition of their cell membranes in both the healthy cells and the cancer cells in the prostate. They had increased levels of omega-3 fatty acids from fish oil and decreased levels of omega-6 fatty acids from corn oil in the cell membranes, which may directly affect the biology of the cells, though further studies are needed, said Dr. William Aronson, the study's first author and a researcher with UCLA's Jonsson Comprehensive Cancer Center.
This is a limited study. A longer term study is being done with patient that doing "Waitful Watching" of their PC rather than active treatment.
More details at the above link.View Thread
The combination of patient and treatment factors showed good correlation with two-year sexual-function outcomes for men treated with surgery or radiation therapy."
For those that are trying to make up their mind about which treatment that they should have ask your doctor to look this up and figure it for you.View Thread
Are you a man with advanced prostate cancer (or his wife, partner or caregiver) who is treating advanced prostate cancer with some of the newest treatment options available? If so, please consider sharing your experiences with the new treatments. This research will be used to improve support services for other patients and their families.
The Frankel Group, a life science focused consulting firm, is seeking participants for a 30-minute telephone discussion. Your identity will be kept completely confidential at all times. For your time, they will offer you a $50 honorarium.
For detail click on the link above.View Thread
This multisite trial will test the results of assigning men with small, low-grade prostate tumors to an intervention designed to encourage a diet low in animal products. The MEAL trial is now open at RPCI and other sites through several cooperative oncology groups sponsored by the National Cancer Institute. Dr. Mohler is Senior Vice President for Translational Research and Chair of the Department of Urology, and Dr. Marshall is Senior Vice President for Cancer Prevention and Population Sciences.
Their team will identify 450 men with prostate cancer from across the country, all considered to be at low risk for developing advanced prostate cancer. All participants will change their dietary intake, but half will more significantly change their diet, assisted by a telephone intervention.
Research has shown that a diet low in animal products like meat and dairy and high in fruits and vegetables is associated with lower incidence of prostate cancer. Drs. Marshall and Mohler and colleagues led a similar six-month pilot study launched in 2004.
"The MEAL trial promises to be a very strong study based in biological and behavioral changes," said Dr. Marshall, who is also Roswell Park Alliance Foundation Endowed Chair in Cancer Prevention. "We've shown very convincingly with our pilot study that we can change men's diets we can see the progress in diet records but, more importantly, by means of blood-based nutritional biomarkers."
The research is supported by the National Cancer Institute, the Department of Defense and The Prostate Cancer Foundation. The MEAL trial will have two important collaborators: J. Kellogg Parsons, MD, MHS, and John Pierce, PhD, both researchers with the Moores Center, UC San Diego.
"The most common question that a urologist gets from a patient who has low-risk prostate cancer is, 'Is there anything I can do to slow or stop its growth should I change my diet?' And this trial should give us much clearer and perhaps even definitive answers," notes Dr. Mohler.
Source: Roswell Park Cancer Institute [a name="ratethis">View Thread
Division of Hematology/Oncology, Department of Medicine, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94143, USA.
Androgen deprivation therapy (ADT) is standard of care for patients with metastatic hormone-sensitive prostate cancer (HSPC), yet through its induction of a hypogonadal state leads to metabolic perturbations, including insulin resistance (IR) and obesity. IR and obesity have been associated with an increased risk of progression to castrate-resistant prostate cancer (CRPC) and ultimately increased prostate cancer-specific mortality. On a molecular level, this association between obesity/IR and prostate cancer progression may be mediated by alterations in the insulin-like growth factor (IGF) axis, which has been shown to be up-regulated upon disease progression to CRPC. Targeting the IGF axis, either by anti-IGF therapy or via enhancement of peripheral insulin sensitivity, represents a viable therapeutic target in patients with prostate cancer. Using the development of IR and/or obesity may represent a clinically available biomarker that may predict those patients most likely to respond to such therapy, and warrants testing in future prospective clinical trials.
Written by:
Aggarwal RR, Ryan CJ, Chan JM. Are you the author?
Reference: Urol Oncol. 2011 Jun 7. Epub ahead of print.
doi: 10.1016/j.urolonc.2011.05.001
[a>PubMed Abstract
PMID: 21658978
UroToday.com Prostate Cancer SectionView Thread
Of 315 patients who'd had their prostate removed due to cancer, only a quarter said a year or more after surgery that they never experienced any leakage.
Still, more than three-quarters of the men said they didn't use pads in their underwear and only about one in 20 said they were significantly bothered by incontinence.
"The bottom line is that many men, after having their prostate removed, will have some impact on the way they urinate," said Dr. Erik Castle, an associate professor of urology at the Mayo Clinic in Phoenix, who led the new work. "But the degree of the impact is minimal.
According to the American Cancer Society, one in six men gets prostate cancer at some point in his life and one in 36 men in the U.S. will die from it.
While there is controversy over how to treat low-risk tumors, some of which may never cause any harm if left untreated, surgery and radiation are common options when the disease is more advanced.
But men considering these treatments also face possible side effects like becoming incontinent or impotent. And getting useful information about how common these problems are is difficult, Castle said, because there are so many different ways of defining them.
"There is a lot of miscommunication," he told Reuters Health. "The goal of the study was to come up with a more detailed analysis of what men should expect after their prostate is removed."
The researchers sent out questionnaires to 600 men, from 42 to 82 years old, who'd had robot-assisted prostate surgery at their hospital.
The surveys focused on incontinence, asking a wealth of questions, including how the patient's sex life, physical activity and social life were affected.
Just over two-thirds of the men responded. At least one year after their surgery, 78 percent said they didn't use pads in their underwear, while only 26 percent said they never leaked.
"The outcomes are actually pretty darn good," said Castle, adding that some of the older men might already have been leaking before they underwent surgery.
Men who used more than one pad a day -- 17 percent -- most often leaked during exercise or when coughing and sneezing, and said their incontinence was most bothersome in relation to their sex life.
Overall, five percent of men said they were significantly bothered by their incontinence, and less than one percent reported leaking all the time.
"We just wanted to get the message across that, 'Look, the vast majority of patients had some kinds of changes in their lifestyle but are still very happy,'" Castle said, adding that less than one percent of patients have any major complications at Mayo Clinic.
Prostate removal is usually only recommended for men who are expected to live at least 10 to 15 more years. And even then, the decision should be based on individual preferences, Castle said.
For instance, if a man already has some incontinence and impotence, Castle would encourage surgery. But if he is very worried about impotence, radiation treatment might be a better way to go, because its effect on continence and potency are delayed a few years, he added.
"This study armed us with the information to be able to explain to patients what to expect when we are counseling them," Castle told Reuters Health. "We end up getting patients who say, 'Doctor, I'm very happy.'"
SOURCE: bit.ly/koe8mc The Journal of Urology, online May 14, 2011.
"View Thread
"This has been the subject of much debate and it's encouraging to see there is validity in aggressive prostate cancer treatment in men below 65, and even those with low risk cancer, rather than waiting for the disease to get worse," said robotic prostate surgery expert Dr. David Samadi, Vice Chairman, Department of Urology, and Chief of Robotics and Minimally Invasive Surgery at The Mount Sinai Medical Center in New York City. "Nerve-sparing robotic prostatectomy is wonderful option for patients because it not only cures them of cancer, but also preserves their sexual and urinary function so they can be cancer-free and maintain a high quality of life."
In the past, some have argued that robotic prostatectomy may be an unnecessary treatment option for men with low risk prostate cancer. This study presents a cogent and convincing argument against such claims, since it was particularly younger men with low risk cancer who demonstrated the mortality benefit after undergoing surgery. Furthermore, younger men also hold up very well against surgical complications because of their age, and if operated on robotically, can likely return home after a single night's hospital stay."View Thread
Analyzing data from a nationwide study involving more than 3,400 men, researchers at Fred Hutchinson Cancer Research Center found that men with the highest blood percentages of docosahexaenoic acid, or DHA, an inflammation-lowering omega-3 fatty acid commonly found in fatty fish, have two-and-a-half-times the risk of developing aggressive, high-grade prostate cancer compared to men with the lowest DHA levels.
Conversely, the study also found that men with the highest blood ratios of trans-fatty acids — which are linked to inflammation and heart disease and abundant in processed foods that contain partially hydrogenated vegetable oils — had a 50 percent reduction in the risk of high-grade prostate cancer. In addition, neither of these fats was associated with the risk of low-grade prostate cancer risk. The researchers also found that omega-6 fatty acids, which are found in most vegetable oils and are linked to inflammation and heart disease, were not associated with prostate cancer risk. They also found that none of the fats were associated with the risk of low-grade prostate cancer.
These findings by Theodore M. Brasky, Ph.D., and colleagues in the Hutchinson Center's Public Health Sciences Division were published online April 25 in the American Journal of Epidemiology.
"We were stunned to see these results and we spent a lot of time making sure the analyses were correct," said Brasky, a postdoctoral research fellow in the Hutchinson Center's Cancer Prevention.
. . .
Among the study participants, very few took fish oil supplements — the most common non-food source of omega-3 fatty acids, which are known to prevent heart disease and other inflammatory conditions. The majority got omega 3s from eating fish.
So based on these findings, should men concerned about heart disease eschew fish oil supplements or grilled salmon in the interest of reducing their risk of aggressive prostate cancer? Brasky and colleagues don't think so.
"Overall, the beneficial effects of eating fish to prevent heart disease outweigh any harm related to prostate cancer risk," Brasky said. "What this study shows is the complexity of nutrition and its impact on disease risk, and that we should study such associations rigorously rather than make assumptions," Brasky said.
The National Cancer Institute funded this study, which also involved researchers from the University of Texas Health Science Center at San Antonio and the NCI."
However this contradicts other studies.
http://www.webmd.com/prostate-cancer/news/20090324/fatty-fish-may-cut-prostate-cancer-risk
"
Fatty Fish May Cut Prostate Cancer Risk Study Shows Eating Fish High in Omega-3s Reduces Risk of Aggressive Prostate Cancer"
However, the big difference is that this new study is based on the amount of fats in the blood and most of the other have been on consumption.
It is possible that thing that is common to aggressive PC causes the blood level to be maintained at a high level.
But as someone that has both CAD (70% blockage of the left main and CABG) and a moderate risk PC (3+7) & prostatectomy I am going to maintain my consumption of fish oil and fatty fish.View Thread
Men with high-risk prostate cancer who take statin drugs commonly used to lower cholesterol while receiving radiation therapy are less likely to have their cancer return than patients who do not take these medications, according to a study published in the March issue of the International Journal of Radiation Oncology-Biology-Physics, an official journal of the American Society for Radiation Oncology (ASTRO).
In the study, 1,681 men with high-risk, localized prostate cancer were treated with radiation therapy between 1995 and 2007. Of them, 382 (23 percent) were taking statin medication at diagnosis and throughout the treatment. Statins are a class of drugs used to lower the cholesterol level in people with or at risk of cardiovascular disease. The median follow-up time was approximately six years.
Researchers found that the men taking statins were less like to relapse than other patients. At five years, 11 percent of men taking statins saw their cancer return compared to 17 percent of patients not taking the medication. At eight years, 17 percent of men on statins had a relapse compared to 26 percent not taking the drug.
"In our retrospective study, we have demonstrated that statin use during radiotherapy is associated with improved biochemical tumor control among high-risk patients," Michael J. Zelefsky, M.D., the senior author of the study and a radiation oncologist at Memorial Sloan-Kettering Cancer Center in New York, said. "This study, along with other emerging studies, strongly suggests that statin use improves outcomes in patients treated with definitive radiation therapy.""View Thread
The findings, published online this month by the journal European Urology, follow an earlier Henry Ford study that found nearly 87 percent of patients whose cancerous prostates were removed by robot-assisted surgery had no recurrence of the disease after five years."
"Confronted, in a sense, by "apples and oranges" comparisons of several RP surgical techniques, the Henry Ford researchers set out to produce a five-year safety study that both concentrated on RARP and incorporated an exhaustive collection of data, covering everything from length of hospital stay, to an in-depth examination of other diseases afflicting the patients, but unrelated to their cancers.
Among the study group of 3,317 RARP patients, researchers found a median hospitalization time of only one day. There were 368 complications in 326 of the patients or 9.8 percent of the total most of which were minor and occurred within 30 days of the surgery.
A patient's prostate-specific antigen (PSA) scores before surgery, as well as cardiac disease, were found to predict medical complications after the robot-assisted surgery; age, gastroesophageal reflux disease (GERD ), and biopsy score predicted possible surgical complications.
The researchers' main conclusion was that "RARP is a safe operation.""
""While these results provide strong endorsement for robotic surgery, we want to emphasize that the results are dependent more on the surgical team that controls the da Vinci robot rather than just the robot," Dr. Menon states."View Thread
Lower-powered lasers are not as effective at removing as much of the enlarged prostate tissues and are therefore less effective.View Thread
Here is why:
There are a lot of different prostate cancer symptoms.
Many of them include things like finding blood in your urine when you go to the bathroom. Or, even finding blood in your semen after having sex. You might also be having troubles peeing -- where you can't get a stream started very easily. And even if you do get it started, it just trickles out, weak and dribbling.
You could also be having sexual dysfunction, too.
But, guess what?
While all these are signs of prostate cancer, they are also prostate symptoms that could indicate other (non life threatening) problems.
It could simply be an enlarged prostate (i.e. BPH).
Or maybe a prostate infection -- also called prostatitis.
In fact, all of these prostate problems symptoms are interchangeable.
Many of the same symptoms of enlarged prostate are the same as symptoms of prostatitis.View Thread
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