Hi I have been disgnosed with RA from 2004 onwards it started with my shoulder and from then I am being on medication Methotrxate 15mg weekly and HCQS daily and time to time on corticosteroids. But the symptoms are getting worser and I am having persistant pain and swelling in my right wrist nothing is helping. My ESR IN 20 and CRP is negative, Anti Nuclear Antibody tested in 1:80. Need some advice what to do next.View Thread