I've been treated with MTX this will be my second time trying it,my doctor has told me to take it once a day six days a week and skip the one day.my dose is 2.5 mgs a day..I've read everywhere that it is not safe to take this medicine daily.Just want to know if anyone else has been prescribed this medication to be taken this way.I.ve been diganosied with reactive arthritis. All of my symptoms began in December of 2011.I.m on the remicade infusion every 8 weeks also.Plus a number of other medications.View Thread