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acceptable. Don't order a combined HSV 1/2 test (i.e. a test that does not look for HSV1 and HSV 2 separately), and IgM tests' usefulness is very controversial. None of the FDA-cleared IgM tests are type-specific, so HSV IgM testing can give false positive results and is often not appropriate for diagnosing herpes. Why? There is crossreactivity
between HSV 1 and HSV 2 (you could tell someone with cold sores that they have genital herpes — in fact, new genital herpes!). In addition, there may be crossreaction with other viruses; and finally, people with well-established herpes can periodically generate IgM antibodies so you can't reliably sort out new from old infection with HSV IgM. Basing a diagnosis of genital herpes on IgM results alone can mean a wrong — and very distressing - diagnosis for your patients. Then what I read goes on to say this:
When you get the test results back, you'll see a numeric value called an index value, along with an interpretation of positive or negative. By package insert, any index value greater than 1.1 in considered positive. However, recent research has shown it not to be quite that simple. The sensitivity of the type specific IgG tests for HSV 2 in an STD
clinic population is about 98% and for HSV 1, 91% (it misses about one out of 10). The specificity of the HSV 2 test is about 97%. Basically, that means there could be 3 false positives out of 100 positive tests. Studies indicate that most of the false positives occur with index values between 1.1 and 3.5 (low positives); it rarely happens with index
values over 3.5. For those with low positive results, it is recommended to confirm testing by a second kind of test, perhaps herpes Western blot from the University of Washington.
if you recall my lab was tested for that HSV IgG/IgM and the results had a HSV1/2 AB so do you think that could have an effect on why the HSV1 didn't show up and maybe it really isn't HSV2? I'm sorry to ask so many questions but you and others on here seem to know more than my doctors at this point and I hate to say that because I really like my doctor but this has really devastated me. Thank you in advance to you and anyone else that may have a answer.
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Lab: HSVIGG/IGM
Name Value Reference Range
HSV 1/2 IGM AB Negative Negative N
HSV1 IGG Serum Negative Negative N HSV2 IGG Serum Positive Negative N
Results: HSV1 Negative, HSV2 Positive
Please Help I have never had anything down there but as a kid I did have cold sores.
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