A high concentration of arterial bolus of nicotine reaches the brain through blood. It is more like having a nicotine pill or an injection to increase its concentration in blood. Nicotine reaches the brain within 10-16 seconds that is faster than intravenous injections. In the brain, interaction of nicotine with Nicotine Acetylcholine receptors (nAChRs), a neurotransmitter (along with associated actions of nicotine) activates Dopamine Pathways. In other words, it induces the release of Dopamine (neurotransmitter). Acetylcholine in central nervous system plays a role in attention and arousal and in other parts to activate muscles. Dopamine gives a feeling of pleasure and satisfaction. Drugs that influence nAChRs can be agonists . Nicotine acts as a nAChRs agonist. Nicotinic as an agonist mimics the action of acetylcholine (ACh) at nicotinic acetylcholine receptors .The nAChRs is named for its affinity for nicotine. A chronic smoker in order to experience the state of arousal maintains high concentration nicotine in blood by frequently consuming cigarette or tobacco. View Thread
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