So glad that I found this site. I have been slowly coming off my Effexor along with going on Welbutrin. I went from 225mg, with Welbutrin for a month, to 150mg with Wellbutrin for a month, to 75mg with Wellbutrin for a mont. Each month was not too bad. Brain zaps that I was able to deal with and it was only for a day or two. But, my last pill of 75mg was Monday. Tuesday was't too bad, but then I could not even get out of my sleep on Wednesday. Literally could not wake up, never called work, people were calling me and I could not get out of the sleep. Thursday was bad as well, but I could get up. Late, but I got up, however the brain zaps and being nauseous were bad. By Friday everything got even worse and I had all symptoms along with crying constantly. Today (Saturday) I woke up and thought it might have been a little better, but nope. I could not stop crying or throwing up. The brain zaps were out of control and the exhaustion was nuts. The screaming in the middle of the night because of the nightmares. I had to have my husband go fill the prescription and go back on it at least for now. I definitely cannot go from 75mg, to 0. I couldn't handle it. I have to work and I have to live. I will work to continue to come off it, but not going 75mg to 0. I will have to take another couple of months to come off slowly!! I was so glad to see that I was not nuts and it is not only me that had these issues. I knew there were side effects of coming off it, but wow is about all I can say!! Will NOT be doing that again.View Thread