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Anyway, how do I deal with this sadness? I belong to a knitting group and a Friday lunch group and a Wednesday rosary making group with church and work out M-F at our rec ctr and a Bible study group on Tues. Weekends are so boring - we mainly have elderly people living here and lots of welfare.
I am searching for how I can change my mood and be a little happier. I know traveling is the key but we don't like driving in traffic.
Anyway, can someone give me some advice - maybe others are in the same boat. I went to senior center yesterday to play bingo - depressed me with the people who were there - no interesting conversation - I call them deadbeats and poorly and unclean dressed people there. My environment is just getting more depressing as I look around - no jobs here so when each year passes our town just gets smaller and stores close,. We are farmers - live in a nice neighborhood but my neighbors are young with little kids and is very clicky - I'm looked as "old" I am a young 72 year old.
Anyway, thanks for listening. I will await someone's response.View Thread




I appear to be what is alternately referred to as an ultra-extensive or ultra-rapid metabolizer. Following both an emergency appendectomy (midazolam administered, possibly with other meds) and a colonoscopy (midazolam and propofol as "twilight sedation"), I was informed both times that it was very difficult to keep me sedated. I have never had any notable sedative effect from any of the benzodiazepines, the so-called "Z drugs", antipsychotics, and even off-label uses of meds like hydroxyzine and dextromethorphan. I've had no response (favorable or negative) from many SSRI, SNRI, and tricyclic antidepressants. I also seem to have a considerable tolerance for chemicals such as ethanol and nicotine.
Of the many medications I've tried, I've found only two that have a demonstrable sedative effect, promethazine and off-label quetiapine. Both are quite effective somnifacients, but of little benefit to the constant exhaustion whenever awake. Nitrous oxide during dental procedures does have a calming effect without hallucinatory aspects, but only at exaggerated levels (as high as 80% mixed with 20% oxygen, or so I'm told).
Clearly, this has made it quite difficult to find depression medications that are effective. (By now, I'm fairly sure I qualify for the "refractory" definition of depression.) Venlafaxine and desvenlafaxine both introduce derealization (specifically, the "dolly zoom" effect some patients report), but no other NRI meds (such as desipramine) have ever been found to cause such effects.
After extensive research and a lack of answers from various physicians, I'm finding myself wondering if this is an issue of drug metabolism related to an issue with CYP deactivation or biodeactivation. If so:
• What options exist for testing of CYP function?
• If a genetic problem with CYP function is found, what options are there for treating it?
If CYP function seems an unlikely scenario, what other areas might be suggested for investigation?
Non-medicinal therapies (psychiatry, psychology, hypnosis, cognitive behavioral therapy, excercise, etcetera) have all been unsuccessful, and I'm becoming desperate for something that will be effective in this decades-long battle. Thanks for any observations or input you can offer!View Thread





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deep breathing50% (1)
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Does any one else feels like that it just makes me very depress usually goes away on it own. Is it anxiety or depression .View Thread



In a nutshell, I have been bullied at almost anywhere. I am now lonely and exhausted. I value friendship and love, I had tried to be more social, they just don't appreciate it. Tried dressing nicely, talkative and being humorous.
Although I am sincere, they still label me as "eccentric". In the past, a guy left me for another girl, he said that I am an easy target and he's tired of defending me.
I've struggled to live a better life, I guess it will never improve.View Thread






Just reaching out....View Thread









Please give it a try
BillView Thread









it seems more and more I'm having trouble with dealing with stressful situations or uncertainties that always happen in life. it gets to the point where I have anxiety attacks and can barley pry myself out of bed. I seem to just get almost debilitatingly tired where it feels like I can sleep for days and it still wouldn't be enough.
any understanding, help, recommendations or just someone to talk to about how I feel would be greatly appreciated. Thank youView Thread








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